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| 26.10.2010 | 20:30 | Sporting Charleroi | - | Waasland-Beveren | 1:2 (1:0) | |
| 20:30 | KV Kortrijk | - | Excelsior Virton | 2:1 (0:0) ap | ||
| 27.10.2010 | 19:30 | KAA Gent | - | KVK Tienen | 4:1 (2:0) | |
| 20:00 | KRC Genk | - | KVV Coxyde | 3:0 (1:0) | ||
| 20:00 | KFC Lille | - | Cercle Brugge | 0:4 (0:2) | ||
| 20:30 | Club Brugge KV | - | Lommel United | 3:1 (2:0) | ||
| 20:30 | KVC Westerlo | - | KSV Roeselare | 2:0 (0:0) | ||
| 20:30 | Germinal Beerschot | - | Eendracht Aalst | 3:0 (2:0) | ||
| 20:30 | Lierse SK | - | Rupel Boom FC | 4:0 (3:0) | ||
| 20:30 | KAS Eupen | - | KV Turnhout | 2:1 (1:0) | ||
| 20:30 | R. White Star Woluwe FC | - | SV Zulte Waregem | 2:1 (1:1) | ||
| 20:30 | RFC Tournai | - | Sint-Truidense VV | 2:1 (1:0) | ||
| 20:30 | KV Mechelen | - | KRC Waregem | 7:0 (3:0) | ||
| 20:30 | URS du Centre | - | RSC Anderlecht | 1:4 (2:1, 2:2, 2:2) tab | ||
| 20:30 | Standaard Wetteren | - | Sporting Lokeren | 2:4 (1:1, 2:2) ap | ||
| 20:45 | Standard Liège | - | Royal Antwerp FC | 2:1 (1:1) |
