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| 26.12.2015 | 14:30 | KV Kortrijk | - | Club Brugge KV | 1:4 (1:1) | |
| 18:00 | Sporting Charleroi | - | KRC Genk | 1:0 (0:0) | ||
| 20:00 | KV Mechelen | - | KAA Gent | 2:0 (0:0) | ||
| 20:00 | Waasland-Beveren | - | Sporting Lokeren | 2:3 (2:0) | ||
| 20:30 | Sint-Truidense VV | - | Oud-Heverlee Leuven | 2:2 (0:1) | ||
| 27.12.2015 | 14:30 | Standard Liège | - | Royal Mouscron-Péruwelz | 3:0 (1:0) | |
| 18:00 | RSC Anderlecht | - | KVC Westerlo | 2:1 (1:0) | ||
| 20:00 | SV Zulte Waregem | - | KV Oostende | 1:0 (0:0) |
| » Classement | équipe recevante | à l'extérieur | Premier tour | Second tour |
| # | Équipe | M. | G. | N. | P. | Buts | Diff. | Pts. | |
|---|---|---|---|---|---|---|---|---|---|
| 1 |
|
KAA Gent | 21 | 12 | 7 | 2 | 40:19 | 21 | 43 |
| 2 |
|
RSC Anderlecht | 21 | 11 | 8 | 2 | 35:17 | 18 | 41 |
| 3 |
|
Club Brugge KV | 21 | 13 | 1 | 7 | 42:25 | 17 | 40 |
| 4 |
|
KV Oostende | 21 | 11 | 5 | 5 | 38:23 | 15 | 38 |
| 5 |
|
SV Zulte Waregem | 21 | 9 | 6 | 6 | 37:34 | 3 | 33 |
| 6 |
|
Sporting Charleroi | 21 | 8 | 6 | 7 | 24:23 | 1 | 30 |
| 7 |
|
KRC Genk | 21 | 8 | 4 | 9 | 23:22 | 1 | 28 |
| 8 |
|
Standard Liège | 21 | 8 | 4 | 9 | 28:36 | -8 | 28 |
| 9 |
|
Sporting Lokeren | 21 | 7 | 6 | 8 | 26:26 | 0 | 27 |
| 10 |
|
KV Mechelen | 21 | 7 | 4 | 10 | 31:37 | -6 | 25 |
| 11 |
|
KV Kortrijk | 21 | 6 | 7 | 8 | 21:27 | -6 | 25 |
| 12 |
|
Sint-Truidense VV | 21 | 7 | 4 | 10 | 22:30 | -8 | 25 |
| 13 |
|
Waasland-Beveren | 21 | 7 | 3 | 11 | 28:39 | -11 | 24 |
| 14 |
|
Royal Mouscron-Péruwelz | 21 | 5 | 6 | 10 | 28:34 | -6 | 21 |
| 15 |
|
Oud-Heverlee Leuven | 21 | 5 | 4 | 12 | 28:38 | -10 | 19 |
| 16 |
|
KVC Westerlo | 21 | 3 | 7 | 11 | 22:43 | -21 | 16 |
| Play-off | |
| Play-off | |
| Relégation |
