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| H (Match allé) | Royal Pari | - | Real Potosí | 2:1 (1:1) | ||
| R (match retour) | Real Potosí | - | Royal Pari | 4:3 (1:0, 3:0) tab | ||
| H (Match allé): 19.05.2018 21:00 | R (match retour): 26.05.2018 23:15 | vainqueur: Real Potosí | ||||
| H (Match allé) | CD Guabirá | - | Sport Boys Warnes | 2:2 (2:1) | ||
| R (match retour) | Sport Boys Warnes | - | CD Guabirá | 4:5 (0:0, 0:0) tab | ||
| H (Match allé): 20.05.2018 21:00 | R (match retour): 27.05.2018 01:30 | vainqueur: CD Guabirá | ||||
