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| H (Match allé) | Universidad de Chile | - | Cobreloa | 2:1 (1:0) | ||
| R (match retour) | Cobreloa | - | Universidad de Chile | 2:3 (0:0) | ||
| H (Match allé): 07.07.2018 23:30 | R (match retour): 14.07.2018 21:30 | vainqueur: Universidad de Chile | ||||
| H (Match allé) | Deportes Valdivia | - | Barnechea | 0:1 (0:0) | ||
| R (match retour) | Barnechea | - | Deportes Valdivia | 5:4 (0:0, 1:2) tab | ||
| H (Match allé): 08.07.2018 18:30 | R (match retour): 14.07.2018 02:00 | vainqueur: Barnechea | ||||
| H (Match allé) | Cobresal | - | Palestino | 1:1 (1:1) | ||
| R (match retour) | Palestino | - | Cobresal | 1:0 (0:0) | ||
| H (Match allé): 08.07.2018 21:30 | R (match retour): 15.07.2018 00:00 | vainqueur: Palestino | ||||
| H (Match allé) | Audax Italiano | - | Huachipato | 2:1 (2:1) | ||
| R (match retour) | Huachipato | - | Audax Italiano | 1:2 (0:0) | ||
| H (Match allé): 09.07.2018 00:00 | R (match retour): 14.07.2018 18:30 | vainqueur: Audax Italiano | ||||
