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| H (Match allé) | Seattle Sounders | - | Santos Laguna | 0:1 (0:0) | ||
| R (match retour) | Santos Laguna | - | Seattle Sounders | 1:1 (1:0) | ||
| H (Match allé): 03.04.2013 04:00 | R (match retour): 10.04.2013 02:00 | vainqueur: Santos Laguna | ||||
| H (Match allé) | Los Angeles Galaxy | - | CF Monterrey | 1:2 (1:0) | ||
| R (match retour) | CF Monterrey | - | Los Angeles Galaxy | 1:0 (0:0) | ||
| H (Match allé): 04.04.2013 04:00 | R (match retour): 11.04.2013 04:00 | vainqueur: CF Monterrey | ||||
