H (Match allé) Atlético Tucumán / Grêmio - Independiente / River Plate -:-
R (match retour) Independiente / River Plate - Atlético Tucumán / Grêmio -:-
H (Match allé): 24.10.2018 R (match retour): 31.10.2018
H (Match allé) Boca Juniors / Cruzeiro - Colo-Colo / Palmeiras -:-
R (match retour) Colo-Colo / Palmeiras - Boca Juniors / Cruzeiro -:-
H (Match allé): 24.10.2018 R (match retour): 31.10.2018