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| H (Match allé) | Independiente Medellín | - | Atlético Tucumán | 1:0 (1:0) | ||
| R (match retour) | Atlético Tucumán | - | Independiente Medellín | 2:4 (1:0, 1:0) tab | ||
| H (Match allé): 19.02.2020 01:30 | R (match retour): 26.02.2020 01:30 | vainqueur: Independiente Medellín | ||||
| H (Match allé) | Barcelona | - | Cerro Porteño | 1:0 (1:0) | ||
| R (match retour) | Cerro Porteño | - | Barcelona | 0:4 (0:1) | ||
| H (Match allé): 20.02.2020 01:30 | R (match retour): 26.02.2020 23:15 | vainqueur: Barcelona | ||||
| H (Match allé) | Deportes Tolima | - | Internacional | 0:0 (0:0) | ||
| R (match retour) | Internacional | - | Deportes Tolima | 1:0 (1:0) | ||
| H (Match allé): 20.02.2020 01:30 | R (match retour): 27.02.2020 01:30 | vainqueur: Internacional | ||||
| H (Match allé) | Palestino | - | Guaraní | 0:1 (0:1) | ||
| R (match retour) | Guaraní | - | Palestino | 2:1 (0:1) | ||
| H (Match allé): 20.02.2020 23:15 | R (match retour): 27.02.2020 23:15 | vainqueur: Guaraní | ||||
