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| H (Match allé) | Honduras Progreso | - | Real España | 1:1 (1:0) | ||
| R (match retour) | Real España | - | Honduras Progreso | 0:0 (0:0) | ||
| H (Match allé): 19.04.2018 03:15 | R (match retour): 22.04.2018 03:00 | vainqueur: Real España | ||||
| H (Match allé) | Platense | - | Olimpia | 0:0 (0:0) | ||
| R (match retour) | Olimpia | - | Platense | 2:1 (2:0) | ||
| H (Match allé): 20.04.2018 03:15 | R (match retour): 23.04.2018 00:00 | vainqueur: Olimpia | ||||
