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| H (Match allé) | AC Milan | - | Brescia Calcio | 3:1 (2:0) | ||
| R (match retour) | Brescia Calcio | - | AC Milan | 3:4 (1:2) | ||
| H (Match allé): 29.11.2005 21:05 | R (match retour): 11.01.2006 21:00 | vainqueur: AC Milan | ||||
| H (Match allé) | Atalanta | - | Udinese Calcio | 1:0 (0:0) | ||
| R (match retour) | Udinese Calcio | - | Atalanta | 3:1 (1:0) | ||
| H (Match allé): 30.11.2005 18:05 | R (match retour): 11.01.2006 17:30 | vainqueur: Udinese Calcio | ||||
| H (Match allé) | Parma FC | - | Inter | 0:1 (0:0) | ||
| R (match retour) | Inter | - | Parma FC | 0:0 (0:0) | ||
| H (Match allé): 30.11.2005 21:05 | R (match retour): 12.01.2006 21:00 | vainqueur: Inter | ||||
| H (Match allé) | ACF Fiorentina | - | Juventus | 2:2 (1:0) | ||
| R (match retour) | Juventus | - | ACF Fiorentina | 4:1 (3:0) | ||
| H (Match allé): 01.12.2005 21:05 | R (match retour): 10.01.2006 21:00 | vainqueur: Juventus | ||||
| H (Match allé) | AS Bari | - | US Palermo | 0:0 (0:0) | ||
| R (match retour) | US Palermo | - | AS Bari | 5:4 (2:1) | ||
| H (Match allé): 07.12.2005 18:00 | R (match retour): 10.01.2006 15:00 | vainqueur: US Palermo | ||||
| H (Match allé) | Lazio Roma | - | AS Cittadella | 2:0 (1:0) | ||
| R (match retour) | AS Cittadella | - | Lazio Roma | 0:0 (0:0) | ||
| H (Match allé): 08.12.2005 15:00 | R (match retour): 12.01.2006 15:30 | vainqueur: Lazio Roma | ||||
| H (Match allé) | SSC Napoli | - | AS Roma | 0:3 (0:2) | ||
| R (match retour) | AS Roma | - | SSC Napoli | 2:1 (2:0) | ||
| H (Match allé): 08.12.2005 15:00 | R (match retour): 11.01.2006 17:00 | vainqueur: AS Roma | ||||
| H (Match allé) | Cagliari Calcio | - | Sampdoria | 1:1 (0:0) | ||
| R (match retour) | Sampdoria | - | Cagliari Calcio | 2:1 (0:0) | ||
| H (Match allé): 08.12.2005 18:00 | R (match retour): 11.01.2006 20:30 | vainqueur: Sampdoria | ||||
