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| H (Match allé) | Deportivo Toluca | - | Monarcas Morelia | 2:1 (0:0) | ||
| R (match retour) | Monarcas Morelia | - | Deportivo Toluca | 2:1 (2:1) | ||
| H (Match allé): 23.11.2017 02:30 | R (match retour): 26.11.2017 04:00 | |||||
| H (Match allé) | Club León | - | UANL Tigres | 1:1 (0:0) | ||
| R (match retour) | UANL Tigres | - | Club León | 1:1 (1:1) | ||
| H (Match allé): 23.11.2017 04:36 | R (match retour): 26.11.2017 02:00 | |||||
| H (Match allé) | Cruz Azul | - | CF América | 0:0 (0:0) | ||
| R (match retour) | CF América | - | Cruz Azul | 0:0 (0:0) | ||
| H (Match allé): 24.11.2017 02:30 | R (match retour): 27.11.2017 03:00 | |||||
| H (Match allé) | Atlas Guadalajara | - | CF Monterrey | 1:2 (1:2) | ||
| R (match retour) | CF Monterrey | - | Atlas Guadalajara | 4:1 (4:1) | ||
| H (Match allé): 24.11.2017 04:30 | R (match retour): 27.11.2017 01:00 | vainqueur: CF Monterrey | ||||
