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| H (Match allé) | Pumas UNAM | - | CF América | 1:4 (1:3) | ||
| R (match retour) | CF América | - | Pumas UNAM | 2:1 (1:1) | ||
| H (Match allé): 03.05.2018 02:30 | R (match retour): 06.05.2018 02:00 | vainqueur: CF América | ||||
| H (Match allé) | Club Tijuana | - | CF Monterrey | 1:1 (0:1) | ||
| R (match retour) | CF Monterrey | - | Club Tijuana | 1:2 (0:2) | ||
| H (Match allé): 03.05.2018 04:30 | R (match retour): 06.05.2018 04:00 | vainqueur: Club Tijuana | ||||
| H (Match allé) | UANL Tigres | - | Santos Laguna | 2:0 (1:0) | ||
| R (match retour) | Santos Laguna | - | UANL Tigres | 2:0 (1:0) | ||
| H (Match allé): 04.05.2018 02:30 | R (match retour): 07.05.2018 01:00 | |||||
| H (Match allé) | Monarcas Morelia | - | Deportivo Toluca | 2:2 (0:1) | ||
| R (match retour) | Deportivo Toluca | - | Monarcas Morelia | 2:2 (1:0) | ||
| H (Match allé): 04.05.2018 04:30 | R (match retour): 06.05.2018 19:00 | |||||
