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| H (Match allé) | CF Monterrey | - | Pumas UNAM | 2:0 (1:0) | ||
| R (match retour) | Pumas UNAM | - | CF Monterrey | 2:0 (0:0) | ||
| H (Match allé): 08.05.2019 16:00 | R (match retour): 11.05.2019 19:00 | |||||
| H (Match allé) | Club Necaxa | - | Atlas Guadalajara | 1:2 (0:2) | ||
| R (match retour) | Atlas Guadalajara | - | Club Necaxa | 6:1 (2:1) | ||
| H (Match allé): 08.05.2019 16:00 | R (match retour): 11.05.2019 16:00 | vainqueur: Atlas Guadalajara | ||||
| H (Match allé) | CF Pachuca | - | Monarcas Morelia | 1:1 (0:0) | ||
| R (match retour) | Monarcas Morelia | - | CF Pachuca | 1:1 (1:0) | ||
| H (Match allé): 08.05.2019 17:00 | R (match retour): 11.05.2019 17:00 | |||||
| H (Match allé) | CF América | - | Santos Laguna | 0:0 (0:0) | ||
| R (match retour) | Santos Laguna | - | CF América | 2:1 (0:0) | ||
| H (Match allé): 09.05.2019 16:00 | R (match retour): 12.05.2019 16:00 | vainqueur: Santos Laguna | ||||
