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| 05.10.2018 | 18:30 | Arsenal Tula | - | FK Ufa | 1:1 (0:1) | |
| 06.10.2018 | 13:00 | Krylia Sovetov | - | Dinamo Moskva | 1:0 (0:0) | |
| 15:30 | FK Rostov | - | FK Orenburg | 0:1 (0:1) | ||
| 18:00 | Rubin Kazan | - | FK Ural | 1:0 (1:0) | ||
| 07.10.2018 | 10:30 | Enisey Krasnoyarsk | - | Spartak Moskva | 2:3 (0:0) | |
| 13:00 | Akhmat Grozny | - | Anzhi Makhachkala | 0:0 (0:0) | ||
| 15:30 | Zenit St. Petersburg | - | FK Krasnodar | 2:1 (0:0) | ||
| 18:00 | CSKA Moskva | - | Lokomotiv Moskva | 0:1 (0:0) |
| » Classement | équipe recevante | à l'extérieur | Premier tour | Second tour |
| # | Équipe | M. | G. | N. | P. | Buts | Diff. | Pts. | |
|---|---|---|---|---|---|---|---|---|---|
| 1 |
|
Zenit St. Petersburg | 10 | 8 | 1 | 1 | 20:8 | 12 | 25 |
| 2 |
|
FK Krasnodar | 10 | 6 | 1 | 3 | 18:8 | 10 | 19 |
| 3 |
|
FK Rostov | 10 | 5 | 3 | 2 | 10:4 | 6 | 18 |
| 4 |
|
Spartak Moskva | 10 | 5 | 3 | 2 | 10:7 | 3 | 18 |
| 5 |
|
Rubin Kazan | 10 | 4 | 5 | 1 | 12:9 | 3 | 17 |
| 6 |
|
CSKA Moskva | 10 | 4 | 4 | 2 | 14:5 | 9 | 16 |
| 7 |
|
Lokomotiv Moskva | 10 | 4 | 3 | 3 | 11:10 | 1 | 15 |
| 8 |
|
FK Orenburg | 10 | 4 | 2 | 4 | 11:9 | 2 | 14 |
| 9 |
|
Akhmat Grozny | 10 | 3 | 3 | 4 | 9:12 | -3 | 12 |
| 10 |
|
FK Ural | 10 | 3 | 2 | 5 | 10:17 | -7 | 11 |
| 11 |
|
Arsenal Tula | 10 | 2 | 4 | 4 | 11:11 | 0 | 10 |
| 12 |
|
Dinamo Moskva | 10 | 2 | 4 | 4 | 9:10 | -1 | 10 |
| 13 |
|
Anzhi Makhachkala | 10 | 3 | 1 | 6 | 6:15 | -9 | 10 |
| 14 |
|
Krylia Sovetov | 10 | 3 | 1 | 6 | 4:14 | -10 | 10 |
| 15 |
|
FK Ufa | 10 | 2 | 3 | 5 | 7:13 | -6 | 9 |
| 16 |
|
Enisey Krasnoyarsk | 10 | 1 | 2 | 7 | 6:16 | -10 | 5 |
| Champions League | |
| Champions League Quali. | |
| Europa League | |
| Europa League Quali. | |
| Relégation | |
| Relégation |
