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| 27.10.2010 | 13:30 | FK Srem Jakovo | - | Vojvodina | 4:5 (0:1, 2:2) tab | |
| 13:30 | Srem Sremska Mitrovica | - | FK Jagodina | 0:2 (0:1) | ||
| 13:30 | FK Sloboda Point Sevojno | - | FK Metalac | 2:1 (1:0) | ||
| 13:30 | FK Smederevo | - | Teleoptik Zemun | 3:4 (0:0, 0:0) tab | ||
| 13:30 | FK Kolubara | - | Spartak Zlatibor Voda | 1:2 (0:0) | ||
| 13:30 | FK Sinđelić Niš | - | FK Rad Beograd | 4:2 (0:0, 0:0) tab | ||
| 16:00 | Partizan | - | Proleter Novi Sad | 3:0 (1:0) | ||
| 18:00 | Crvena Zvezda | - | Borac Čačak | 4:0 (2:0) |
