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| H (Match allé) | Fatih Karagümrük SK | - | Göztepe | 1:2 (0:1) | ||
| R (match retour) | Göztepe | - | Fatih Karagümrük SK | 2:1 (1:1) | ||
| H (Match allé): 03.12.2019 11:00 | R (match retour): 18.12.2019 16:30 | vainqueur: Göztepe | ||||
| H (Match allé) | Yeni Malatyaspor | - | Keçiörengücü | 3:1 (2:0) | ||
| R (match retour) | Keçiörengücü | - | Yeni Malatyaspor | 2:2 (0:0) | ||
| H (Match allé): 03.12.2019 12:30 | R (match retour): 18.12.2019 11:45 | vainqueur: Yeni Malatyaspor | ||||
| H (Match allé) | Alanyaspor | - | Adanaspor | 5:1 (1:0) | ||
| R (match retour) | Adanaspor | - | Alanyaspor | 1:7 (0:4) | ||
| H (Match allé): 03.12.2019 14:30 | R (match retour): 17.12.2019 16:30 | vainqueur: Alanyaspor | ||||
| H (Match allé) | Erokspor | - | Sivasspor | 0:2 (0:1) | ||
| R (match retour) | Sivasspor | - | Erokspor | 0:1 (0:0) | ||
| H (Match allé): 03.12.2019 16:30 | R (match retour): 18.12.2019 14:30 | vainqueur: Sivasspor | ||||
| H (Match allé) | Fenerbahçe | - | İstanbulspor AŞ | 4:0 (2:0) | ||
| R (match retour) | İstanbulspor AŞ | - | Fenerbahçe | 0:2 (0:0) | ||
| H (Match allé): 03.12.2019 18:45 | R (match retour): 18.12.2019 18:45 | vainqueur: Fenerbahçe | ||||
| H (Match allé) | Hekimoğlu Trabzon | - | İstanbul Başakşehir | 0:1 (0:1) | ||
| R (match retour) | İstanbul Başakşehir | - | Hekimoğlu Trabzon | 2:0 (0:0) | ||
| H (Match allé): 04.12.2019 11:00 | R (match retour): 19.12.2019 14:30 | vainqueur: İstanbul Başakşehir | ||||
| H (Match allé) | Eyüpspor | - | Antalyaspor | 0:3 (0:2) | ||
| R (match retour) | Antalyaspor | - | Eyüpspor | 2:2 (1:1) | ||
| H (Match allé): 04.12.2019 11:45 | R (match retour): 17.12.2019 12:30 | vainqueur: Antalyaspor | ||||
| H (Match allé) | Kasımpaşa SK | - | Vanspor FK | 2:1 (2:1) | ||
| R (match retour) | Vanspor FK | - | Kasımpaşa SK | 2:2 (1:1, 2:1) ap | ||
| H (Match allé): 04.12.2019 12:30 | R (match retour): 17.12.2019 11:00 | vainqueur: Kasımpaşa SK | ||||
| H (Match allé) | BB Erzurumspor | - | Bursaspor | 4:2 (1:1) | ||
| R (match retour) | Bursaspor | - | BB Erzurumspor | 2:1 (0:1) | ||
| H (Match allé): 04.12.2019 14:30 | R (match retour): 19.12.2019 16:30 | vainqueur: BB Erzurumspor | ||||
| H (Match allé) | Altay Izmir | - | Trabzonspor | 1:2 (0:1) | ||
| R (match retour) | Trabzonspor | - | Altay Izmir | 4:1 (0:0) | ||
| H (Match allé): 04.12.2019 16:30 | R (match retour): 19.12.2019 18:45 | vainqueur: Trabzonspor | ||||
| H (Match allé) | Galatasaray | - | Tuzlaspor | 0:2 (0:0) | ||
| R (match retour) | Tuzlaspor | - | Galatasaray | 0:4 (0:3) | ||
| H (Match allé): 04.12.2019 18:45 | R (match retour): 17.12.2019 18:45 | vainqueur: Galatasaray | ||||
| H (Match allé) | Kırklarelispor | - | Gaziantep FK | 2:1 (1:0) | ||
| R (match retour) | Gaziantep FK | - | Kırklarelispor | 3:2 (1:1) | ||
| H (Match allé): 05.12.2019 11:00 | R (match retour): 18.12.2019 12:30 | vainqueur: Kırklarelispor | ||||
| H (Match allé) | Kayserispor | - | Manisa FK | 3:2 (1:0) | ||
| R (match retour) | Manisa FK | - | Kayserispor | 3:3 (1:0) | ||
| H (Match allé): 05.12.2019 12:30 | R (match retour): 19.12.2019 11:00 | vainqueur: Kayserispor | ||||
| H (Match allé) | Altınordu FK | - | Denizlispor | 3:5 (1:1) | ||
| R (match retour) | Denizlispor | - | Altınordu FK | 2:2 (2:0) | ||
| H (Match allé): 05.12.2019 14:30 | R (match retour): 19.12.2019 12:30 | vainqueur: Denizlispor | ||||
| H (Match allé) | Çaykur Rizespor | - | Samsunspor | 3:2 (3:1) | ||
| R (match retour) | Samsunspor | - | Çaykur Rizespor | 1:1 (0:0) | ||
| H (Match allé): 05.12.2019 16:30 | R (match retour): 17.12.2019 14:30 | vainqueur: Çaykur Rizespor | ||||
| H (Match allé) | Beşiktaş | - | 24 Erzincanspor | 3:0 (2:0) | ||
| R (match retour) | 24 Erzincanspor | - | Beşiktaş | 2:0 (1:0) | ||
| H (Match allé): 05.12.2019 18:45 | R (match retour): 18.12.2019 11:00 | vainqueur: Beşiktaş | ||||
