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| H (Match allé) | Chicago Fire | - | D.C. United | 0:0 (0:0) | ||
| R (match retour) | D.C. United | - | Chicago Fire | 0:4 (0:3) | ||
| H (Match allé): 22.10.2005 03:00 | R (match retour): 30.10.2005 22:30 | vainqueur: Chicago Fire | ||||
| H (Match allé) | MetroStars | - | New England Revolution | 1:0 (1:0) | ||
| R (match retour) | New England Revolution | - | MetroStars | 3:1 (0:0) | ||
| H (Match allé): 23.10.2005 01:00 | R (match retour): 30.10.2005 02:00 | vainqueur: New England Revolution | ||||
| H (Match allé) | Colorado Rapids | - | FC Dallas | 0:0 (0:0) | ||
| R (match retour) | FC Dallas | - | Colorado Rapids | 4:5 (0:1, 1:1, 2:2) tab | ||
| H (Match allé): 23.10.2005 03:00 | R (match retour): 30.10.2005 02:30 | vainqueur: Colorado Rapids | ||||
| H (Match allé) | Los Angeles Galaxy | - | San Jose Earthquakes | 3:1 (2:0) | ||
| R (match retour) | San Jose Earthquakes | - | Los Angeles Galaxy | 1:1 (1:0) | ||
| H (Match allé): 23.10.2005 21:00 | R (match retour): 30.10.2005 04:00 | vainqueur: Los Angeles Galaxy | ||||
