Bayer Leverkusen plan to compound Borussia Dortmund's domestic misery when Germany's Champions League sides square off on Saturday at opposing ends of the Bundesliga spectrum following the winter break.

Leverkusen face Atletico Madrid while Dortmund take on Juventus in the last-16 of the Champions League next month, but lie in contrasting situations ahead of the match at Leverkusen's BayArena.

The hosts are third, a staggering 17 points behind run-away leaders Bayern Munich, while Dortmund are second-from-bottom after a disastrous 10 defeats in their first 17 league matches.

Bayer inflicted Dortmund's first defeat back in August with a 2-0 victory at Borussia's Westfalenstadion as Germany winger Karim Bellarabi scored the fastest goal in Bundesliga history by netting after just nine seconds.

"We want to do our thing against Dortmund and pick up the three points," insisted Bellarabi.

Bayer striker Stefan Kiessling acknowledged that Dortmund's desperate desire for points makes them dangerous.

"A defeat for Dortmund certainly wouldn't be the end of their world, but we know what is at stake for them," said the former Germany striker.

The BayArena has been a happy hunting ground for Dortmund in recent years and coach Jurgen Klopp is unbeaten there in Borussia's last six visits.

"I don't write anyone off. I can't imagine things will go as badly for Dortmund in the second half of the season as it did in the first," said Leverkusen's coach Roger Schmidt.

"There are more pleasant teams than us to face as the league resumes.

"Dortmund have players back from injury, but we are also very well equipped. Our players have also recharged their batteries."

Dortmund have Marco Reus and Henrikh Mkhitaryan back from injury and are set to give a Bundesliga debut to new-signing right winger Kevin Kampl, who Schmidt coached at RB Salzburg from 2012 until 2014,

Leverkusen will be without South Korea striker Son Heung-Min and Australia forward Robbie Kruse when their respective teams meet in the Asian Cup final in Sydney (2000 local time) on Saturday.