Bayer Leverkusen are chasing a first Champions League win over Monaco at the sixth attempt on Wednesday with both sides already through to the knock-out stages.

Regardless of the result at Leverkusen's BayArena, Monaco are confirmed as Group E winners while Bayer will progress in second at the expense of Tottenham Hotspur.

The Germans came within a whisker of a win at Monaco when the sides last met in September, leading 1-0 through Javier Hernandez's strike before Kamil Glik equalised for Monaco in the 94th-minute.

Monaco are unbeaten in their five matches against Leverkusen with three wins and two draws and have never lost on their five previous European matches in Germany.

They are in fine form with four wins and a draw from their last five games having trounced Bastia 5-0 at home on Saturday in the French league.

The match is a dead rubber, but Leverkusen need a win to boost confidence following a run of three league games without a victory.

In-form Turkish international Hakan Calhanoglu is expected to partner Javier Hernandez 'Chicharito' in attack in the absence of Kevin Volland, who has a thigh injury.

Swiss striker Admir Mehmedi is also out with a groin injury while Kevin Kampl, who scored in their 1-0 win at Spurs, has been ruled out for the next eight weeks with a foot injury.

Finland striker Joel Pohjanpalo is pushing for a starting berth after recovering from a broken metatarsal.

It will be interesting to see who takes over the penalty duties, should Leverkusen be awarded a spot kick.

Javier Hernandez crashed his effort off the goalkeeper's boot in Saturday's 1-1 draw at Freiburg meaning his club have failed with all four penalties awarded to them in the Bundesliga this season.

The Mexican also failed with a penalty in their 2-1 defeat to Eintracht Frankfurt in September, while Charles Aranguiz and Calhanoglu have also missed spot kicks against Leipzig and Augsburg respectively.

Bayer were also beaten on penalties by third-division club Sportfreunde Lotte in the second round of the DFB Cup.

"Having already missed so many, a lot of players are lacking confidence when it comes to taking penalties, including myself," Calhanoglu admitted in magazine Kicker.

"If we get our next penalty on Wednesday, I'd want to grab the ball and stick it in the back of the net."