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| H (Match allé) | Lobos UPNFM | - | Honduras Progreso | 3:2 (2:1) | ||
| R (match retour) | Honduras Progreso | - | Lobos UPNFM | 4:0 (1:0) | ||
| H (Match allé): 02.05.2021 01:00 | R (match retour): 06.05.2021 03:00 | vainqueur: Honduras Progreso | ||||
| H (Match allé) | Vida | - | Motagua | 1:1 (0:0) | ||
| R (match retour) | Motagua | - | Vida | 3:0 (0:0) | ||
| H (Match allé): 02.05.2021 23:06 | R (match retour): 05.05.2021 03:00 | vainqueur: Motagua | ||||
