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| H (Match allé) | CA Cerro | - | Defensor Sporting | 1:2 (1:1) | ||
| R (match retour) | Defensor Sporting | - | CA Cerro | 0:1 (0:0) | ||
| H (Match allé): 30.11.2021 23:00 | R (match retour): 04.12.2021 01:45 | vainqueur: Defensor Sporting | ||||
| H (Match allé) | Central Español | - | Racing | 0:0 (0:0) | ||
| R (match retour) | Racing | - | Central Español | 1:1 (0:1) | ||
| H (Match allé): 01.12.2021 01:45 | R (match retour): 03.12.2021 23:00 | vainqueur: Central Español | ||||
