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| 13.12.2021 | 15:00 | Excelsior Virton II | - | KV Oostende II | 3:1 | |
| 19:30 | KAS Eupen II | - | Lommel SK II | 4:0 (2:0) | ||
| 19:30 | SK Beveren II | - | KV Kortrijk II | 4:0 | ||
| 19:30 | Royal Excel Mouscron II | - | Lierse Kempenzonen II | 5:0 (4:0) | ||
| 20:00 | Union St. Gilloise II | - | RWDM Brussels FC II | 1:3 (0:2) | ||
| 20:00 | RFC Seraing II | - | K Beerschot VA II | 1:3 (1:0) | ||
| 20:00 | SK Deinze II | - | KVC Westerlo II | 3:2 |
| » Classement | équipe recevante | à l'extérieur | Premier tour | Second tour |
| # | Équipe | M. | G. | N. | P. | Buts | Diff. | Pts. | |
|---|---|---|---|---|---|---|---|---|---|
| 1 |
|
KAS Eupen II | 14 | 10 | 1 | 3 | 33:16 | 17 | 31 |
| 2 |
|
K Beerschot VA II | 14 | 9 | 3 | 2 | 32:14 | 18 | 30 |
| 3 |
|
KV Oostende II | 14 | 7 | 5 | 2 | 33:17 | 16 | 26 |
| 4 |
|
RWDM Brussels FC II | 14 | 8 | 2 | 4 | 38:26 | 12 | 26 |
| 5 |
|
Royal Excel Mouscron II | 14 | 7 | 2 | 5 | 27:14 | 13 | 23 |
| 6 |
|
Excelsior Virton II | 14 | 7 | 2 | 5 | 31:36 | -5 | 23 |
| 7 |
|
SK Beveren II | 14 | 7 | 1 | 6 | 25:14 | 11 | 22 |
| 8 |
|
Union St. Gilloise II | 14 | 6 | 2 | 6 | 17:14 | 3 | 20 |
| 9 |
|
Lierse Kempenzonen II | 14 | 5 | 4 | 5 | 19:30 | -11 | 19 |
| 10 |
|
KVC Westerlo II | 14 | 5 | 2 | 7 | 21:24 | -3 | 17 |
| 11 |
|
SK Deinze II | 14 | 5 | 2 | 7 | 17:27 | -10 | 17 |
| 12 |
|
RFC Seraing II | 14 | 4 | 0 | 10 | 18:32 | -14 | 12 |
| 13 |
|
KV Kortrijk II | 14 | 1 | 3 | 10 | 13:35 | -22 | 6 |
| 14 |
|
Lommel SK II | 14 | 1 | 3 | 10 | 10:35 | -25 | 6 |
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