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| 07.02.2022 | 19:30 | KAS Eupen II | - | SK Beveren II | 2:1 (1:1) | |
| 19:30 | KV Oostende II | - | Lommel SK II | 3:1 (3:1) | ||
| 20:00 | SK Deinze II | - | Lierse Kempenzonen II | 1:3 (0:2) | ||
| 20:00 | RFC Seraing II | - | Royal Excel Mouscron II | 2:2 (1:2) | ||
| 20:00 | Union St. Gilloise II | - | K Beerschot VA II | 0:2 (0:1) | ||
| 20:30 | RWDM Brussels FC II | - | KVC Westerlo II | 0:2 (0:1) | ||
| 04.03.2022 | 15:00 | Excelsior Virton II | - | KV Kortrijk II | 5:2 |
| » Classement | équipe recevante | à l'extérieur | Premier tour | Second tour |
| # | Équipe | M. | G. | N. | P. | Buts | Diff. | Pts. | |
|---|---|---|---|---|---|---|---|---|---|
| 1 |
|
KAS Eupen II | 18 | 14 | 1 | 3 | 46:21 | 25 | 43 |
| 2 |
|
K Beerschot VA II | 18 | 12 | 4 | 2 | 46:18 | 28 | 40 |
| 3 |
|
KV Oostende II | 18 | 9 | 7 | 2 | 46:24 | 22 | 34 |
| 4 |
|
Excelsior Virton II | 18 | 9 | 2 | 7 | 42:46 | -4 | 29 |
| 5 |
|
Royal Excel Mouscron II | 18 | 8 | 4 | 6 | 36:21 | 15 | 28 |
| 6 |
|
SK Beveren II | 18 | 9 | 1 | 8 | 32:20 | 12 | 28 |
| 7 |
|
Union St. Gilloise II | 18 | 8 | 3 | 7 | 25:19 | 6 | 27 |
| 8 |
|
RWDM Brussels FC II | 18 | 8 | 2 | 8 | 41:40 | 1 | 26 |
| 9 |
|
KVC Westerlo II | 18 | 7 | 2 | 9 | 29:32 | -3 | 23 |
| 10 |
|
Lierse Kempenzonen II | 18 | 6 | 4 | 8 | 23:42 | -19 | 22 |
| 11 |
|
RFC Seraing II | 18 | 6 | 1 | 11 | 26:36 | -10 | 19 |
| 12 |
|
SK Deinze II | 18 | 5 | 3 | 10 | 20:40 | -20 | 18 |
| 13 |
|
Lommel SK II | 18 | 3 | 3 | 12 | 16:43 | -27 | 12 |
| 14 |
|
KV Kortrijk II | 18 | 1 | 5 | 12 | 20:46 | -26 | 8 |
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