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| 18.10.2021 | 19:30 | Royal Excel Mouscron II | - | RWDM Brussels FC II | 4:2 | |
| 19:30 | SK Beveren II | - | Excelsior Virton II | 3:2 | ||
| 19:30 | KV Kortrijk II | - | KV Oostende II | 0:0 | ||
| 20:00 | RFC Seraing II | - | SK Deinze II | 0:3 | ||
| 20:00 | KVC Westerlo II | - | Union St. Gilloise II | 1:0 | ||
| 20:00 | K Beerschot VA II | - | Lommel SK II | 4:0 (1:0) | ||
| 20:00 | Lierse Kempenzonen II | - | KAS Eupen II | 1:4 (0:3) |
| » Classement | équipe recevante | à l'extérieur | Premier tour | Second tour |
| # | Équipe | M. | G. | N. | P. | Buts | Diff. | Pts. | |
|---|---|---|---|---|---|---|---|---|---|
| 1 |
|
KAS Eupen II | 7 | 5 | 1 | 1 | 18:8 | 10 | 16 |
| 2 |
|
KV Oostende II | 7 | 3 | 4 | 0 | 17:7 | 10 | 13 |
| 3 |
|
SK Beveren II | 7 | 4 | 1 | 2 | 14:6 | 8 | 13 |
| 4 |
|
Lierse Kempenzonen II | 7 | 4 | 1 | 2 | 10:15 | -5 | 13 |
| 5 |
|
Royal Excel Mouscron II | 7 | 4 | 0 | 3 | 10:5 | 5 | 12 |
| 6 |
|
KVC Westerlo II | 7 | 4 | 0 | 3 | 9:8 | 1 | 12 |
| 7 |
|
K Beerschot VA II | 7 | 3 | 2 | 2 | 12:6 | 6 | 11 |
| 8 |
|
SK Deinze II | 7 | 3 | 1 | 3 | 7:7 | 0 | 10 |
| 9 |
|
Union St. Gilloise II | 7 | 3 | 1 | 3 | 6:7 | -1 | 10 |
| 10 |
|
RFC Seraing II | 7 | 3 | 0 | 4 | 6:9 | -3 | 9 |
| 11 |
|
Excelsior Virton II | 7 | 2 | 2 | 3 | 13:20 | -7 | 8 |
| 12 |
|
RWDM Brussels FC II | 7 | 2 | 1 | 4 | 14:19 | -5 | 7 |
| 13 |
|
Lommel SK II | 7 | 1 | 1 | 5 | 9:16 | -7 | 4 |
| 14 |
|
KV Kortrijk II | 7 | 0 | 1 | 6 | 1:13 | -12 | 1 |
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