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| 19.01.2011 | 20:00 | RBD Borinage | - | FC Brussels | 4:0 (1:0) | |
| 20:00 | RFC Tournai | - | KV Turnhout | 1:1 (1:1) | ||
| 20:00 | KSV Roeselare | - | RAEC Mons | 0:0 (0:0) | ||
| 20:00 | Royal Antwerp FC | - | CS Visé | 2:2 (2:1) | ||
| 20:00 | FCV Dender EH | - | KV Oostende | 1:3 (1:1) | ||
| 20:00 | KVK Tienen | - | AFC Tubize | 1:3 (0:1) | ||
| 20:30 | Lommel United | - | Oud-Heverlee Leuven | 4:1 (2:0) | ||
| 20:30 | Waasland-Beveren | - | Rupel Boom FC | 1:1 (0:0) | ||
| 20:40 | KSK Heist | - | Standaard Wetteren | 1:1 (0:0) |
| » Classement | équipe recevante | à l'extérieur | Premier tour | Second tour |
| # | Équipe | M. | G. | N. | P. | Buts | Diff. | Pts. | |
|---|---|---|---|---|---|---|---|---|---|
| 1 |
|
Lommel United | 17 | 12 | 2 | 3 | 46:22 | 24 | 38 |
| 2 |
|
Oud-Heverlee Leuven | 17 | 10 | 4 | 3 | 36:21 | 15 | 34 |
| 3 |
|
RAEC Mons | 17 | 9 | 5 | 3 | 30:16 | 14 | 32 |
| 4 |
|
Waasland-Beveren | 17 | 8 | 7 | 2 | 27:12 | 15 | 31 |
| 5 |
|
KV Oostende | 17 | 10 | 1 | 6 | 25:23 | 2 | 31 |
| 6 |
|
FCV Dender EH | 17 | 9 | 3 | 5 | 31:20 | 11 | 30 |
| 7 |
|
CS Visé | 17 | 7 | 6 | 4 | 28:22 | 6 | 27 |
| 8 |
|
KSK Heist | 17 | 7 | 5 | 5 | 32:30 | 2 | 26 |
| 9 |
|
Standaard Wetteren | 17 | 6 | 6 | 5 | 24:26 | -2 | 24 |
| 10 |
|
RBD Borinage | 17 | 6 | 3 | 8 | 25:26 | -1 | 21 |
| 11 |
|
Royal Antwerp FC | 17 | 5 | 6 | 6 | 24:30 | -6 | 21 |
| 12 |
|
KVK Tienen | 17 | 6 | 3 | 8 | 18:26 | -8 | 21 |
| 13 |
|
AFC Tubize | 17 | 5 | 4 | 8 | 20:31 | -11 | 19 |
| 14 |
|
Rupel Boom FC | 17 | 5 | 3 | 9 | 16:31 | -15 | 18 |
| 15 |
|
KSV Roeselare | 17 | 4 | 5 | 8 | 20:27 | -7 | 17 |
| 16 |
|
FC Brussels | 17 | 3 | 5 | 9 | 23:29 | -6 | 14 |
| 17 |
|
KV Turnhout | 17 | 2 | 6 | 9 | 17:29 | -12 | 12 |
| 18 |
|
RFC Tournai | 17 | 0 | 4 | 13 | 16:37 | -21 | 4 |
| Promotion | |
| Play-off | |
| Relégation | |
| Relégation |
