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| H (Match allé) | São Paulo FC | - | Athletico Paranaense | 1:1 (0:1) | ||
| R (match retour) | Athletico Paranaense | - | São Paulo FC | 1:0 (1:0) | ||
| H (Match allé): 27.12.2020 20:00 | R (match retour): 03.01.2021 20:00 | vainqueur: Athletico Paranaense | ||||
| H (Match allé) | Flamengo RJ | - | Fluminense RJ | 3:1 (1:1) | ||
| R (match retour) | Fluminense RJ | - | Flamengo RJ | 1:4 (1:0, 3:1, 3:1) tab | ||
| H (Match allé): 28.12.2020 19:00 | R (match retour): 04.01.2021 19:00 | vainqueur: Flamengo RJ | ||||
| H (Match allé) | Palmeiras | - | Atlético Mineiro | 0:0 (0:0) | ||
| R (match retour) | Atlético Mineiro | - | Palmeiras | 1:0 (1:0) | ||
| H (Match allé): 29.12.2020 20:00 | R (match retour): 04.01.2021 00:30 | vainqueur: Atlético Mineiro | ||||
| H (Match allé) | Corinthians SP | - | Grêmio Porto Alegre | 0:0 (0:0) | ||
| R (match retour) | Grêmio Porto Alegre | - | Corinthians SP | 2:3 (2:0) | ||
| H (Match allé): 29.12.2020 20:00 | R (match retour): 03.01.2021 20:00 | vainqueur: Corinthians SP | ||||
