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| H (Match allé) | Ethnikos Achna | - | Enosis Neon Paralimni | 1:0 (0:0) | ||
| R (match retour) | Enosis Neon Paralimni | - | Ethnikos Achna | 0:4 (0:1) | ||
| H (Match allé): 09.03.2022 16:00 | R (match retour): 06.04.2022 16:00 | vainqueur: Ethnikos Achna | ||||
| H (Match allé) | APOEL Nikosia | - | Anorthosis Famagusta | 2:1 (1:1) | ||
| R (match retour) | Anorthosis Famagusta | - | APOEL Nikosia | 1:0 (1:0) | ||
| H (Match allé): 09.03.2022 18:00 | R (match retour): 06.04.2022 18:00 | vainqueur: Anorthosis Famagusta | ||||
| H (Match allé) | AEK Larnaca | - | Onisilos Sotiras | 8:0 (4:0) | ||
| R (match retour) | Onisilos Sotiras | - | AEK Larnaca | 1:5 (0:3) | ||
| H (Match allé): 16.03.2022 17:00 | R (match retour): 13.04.2022 16:00 | vainqueur: AEK Larnaca | ||||
| H (Match allé) | AEL Limassol | - | Omonia Nikosia | 1:1 (0:0) | ||
| R (match retour) | Omonia Nikosia | - | AEL Limassol | 0:0 (0:0) | ||
| H (Match allé): 16.03.2022 18:00 | R (match retour): 13.04.2022 18:00 | vainqueur: Omonia Nikosia | ||||
