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| 29.04.2006 | 14:25 | Slovan Liberec | - | FK SIAD Most | 1:1 (1:0) | |
| 19:00 | Vysočina Jihlava | - | Sigma Olomouc | 3:0 (1:0) | ||
| 20:00 | 1. FC Slovácko | - | FK Marila Příbram | 2:0 (2:0) | ||
| 30.04.2006 | 15:00 | Chmel Blsany | - | Slavia Praha | 1:3 (0:0) | |
| 17:00 | 1. FC Brno | - | FK Mladá Boleslav | 4:2 (2:0) | ||
| 17:00 | Baník Ostrava | - | Viktoria Plzeň | 6:0 (2:0) | ||
| 17:00 | FK Teplice | - | FK Jablonec 97 | 1:1 (1:1) | ||
| 01.05.2006 | 16:45 | AC Sparta Praha | - | Tescoma Zlín | 1:0 (1:0) |
| # | Équipe | M. | G. | N. | P. | Buts | Diff. | Pts. | |
|---|---|---|---|---|---|---|---|---|---|
| 1 |
|
Slovan Liberec | 28 | 16 | 10 | 2 | 40:18 | 22 | 58 |
| 2 |
|
Slavia Praha | 28 | 13 | 9 | 6 | 49:34 | 15 | 48 |
| 3 |
|
FK Teplice | 28 | 11 | 15 | 2 | 34:21 | 13 | 48 |
| 4 |
|
FK Mladá Boleslav | 28 | 14 | 6 | 8 | 43:34 | 9 | 48 |
| 5 |
|
AC Sparta Praha | 28 | 13 | 5 | 10 | 40:34 | 6 | 44 |
| 6 |
|
Baník Ostrava | 28 | 9 | 10 | 9 | 31:27 | 4 | 37 |
| 7 |
|
Sigma Olomouc | 28 | 10 | 6 | 12 | 33:40 | -7 | 36 |
| 8 |
|
FK SIAD Most | 28 | 10 | 5 | 13 | 28:34 | -6 | 35 |
| 9 |
|
FK Jablonec 97 | 28 | 9 | 7 | 12 | 33:38 | -5 | 34 |
| 10 |
|
Tescoma Zlín | 28 | 8 | 10 | 10 | 24:29 | -5 | 34 |
| 11 |
|
FK Marila Příbram | 28 | 8 | 9 | 11 | 34:33 | 1 | 33 |
| 12 |
|
1. FC Slovácko | 28 | 7 | 11 | 10 | 26:28 | -2 | 32 |
| 13 |
|
1. FC Brno | 28 | 6 | 13 | 9 | 31:33 | -2 | 31 |
| 14 |
|
Vysočina Jihlava | 28 | 6 | 11 | 11 | 20:29 | -9 | 29 |
| 15 |
|
Viktoria Plzeň | 28 | 6 | 10 | 12 | 27:40 | -13 | 28 |
| 16 |
|
Chmel Blsany | 28 | 4 | 11 | 13 | 19:40 | -21 | 23 |
| Champions League Quali. | |
| Europa League Quali. | |
| Relégation |
