 |
 |
|
| H (Match allé) | Cruz Azul | - | UANL Tigres | 0:4 (0:3) | ||
| R (match retour) | UANL Tigres | - | Cruz Azul | 4:0 (1:0) | ||
| H (Match allé): 03.12.2021 19:45 | R (match retour): 07.12.2021 02:00 | vainqueur: UANL Tigres | ||||
| H (Match allé) | Santos Laguna | - | Atlas Guadalajara | 2:2 (0:0) | ||
| R (match retour) | Atlas Guadalajara | - | Santos Laguna | 2:1 (1:1) | ||
| H (Match allé): 04.12.2021 01:00 | R (match retour): 06.12.2021 19:00 | vainqueur: Atlas Guadalajara | ||||
| H (Match allé) | CF América | - | Deportivo Guadalajara | 2:1 (2:0) | ||
| R (match retour) | Deportivo Guadalajara | - | CF América | 0:0 (0:0) | ||
| H (Match allé): 04.12.2021 03:00 | R (match retour): 07.12.2021 00:00 | vainqueur: CF América | ||||
| H (Match allé) | Club Tijuana | - | CF Monterrey | 1:1 (1:0) | ||
| R (match retour) | CF Monterrey | - | Club Tijuana | 1:1 (1:1) | ||
| H (Match allé): 04.12.2021 04:30 | R (match retour): 07.12.2021 04:00 | |||||
