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| H (Match allé) | Albinegros Orizaba | - | Club Tijuana | 0:0 (0:0) | ||
| R (match retour) | Club Tijuana | - | Albinegros Orizaba | 0:0 (0:0) | ||
| H (Match allé): 26.11.2010 02:00 | R (match retour): 28.11.2010 22:00 | |||||
| H (Match allé) | Club Irapuato | - | Veracruz (old) | 2:0 (1:0) | ||
| R (match retour) | Veracruz (old) | - | Club Irapuato | 3:1 (1:0) | ||
| H (Match allé): 26.11.2010 03:50 | R (match retour): 29.11.2010 02:00 | vainqueur: Club Irapuato | ||||
