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| H (Match allé) | Atlas Guadalajara | - | Monarcas Morelia | 1:2 (1:1) | ||
| R (match retour) | Monarcas Morelia | - | Atlas Guadalajara | 1:2 (1:2) | ||
| H (Match allé): 27.11.2019 18:00 | R (match retour): 30.11.2019 17:00 | |||||
| H (Match allé) | Club León | - | Deportivo Guadalajara | 0:3 (0:3) | ||
| R (match retour) | Deportivo Guadalajara | - | Club León | 3:2 (2:1) | ||
| H (Match allé): 28.11.2019 16:00 | R (match retour): 01.12.2019 18:00 | vainqueur: Deportivo Guadalajara | ||||
| H (Match allé) | Cruz Azul | - | CF Pachuca | 1:4 (0:1) | ||
| R (match retour) | CF Pachuca | - | Cruz Azul | 3:0 (2:0) | ||
| H (Match allé): 28.11.2019 17:00 | R (match retour): 01.12.2019 17:00 | vainqueur: CF Pachuca | ||||
| H (Match allé) | Club Tijuana | - | Santos Laguna | 3:0 (2:0) | ||
| R (match retour) | Santos Laguna | - | Club Tijuana | 1:2 (0:2) | ||
| H (Match allé): 29.11.2019 06:00 | R (match retour): 01.12.2019 16:00 | vainqueur: Club Tijuana | ||||
