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| H (Match allé) | CF América | - | CF Monterrey | 1:2 (1:2) | ||
| R (match retour) | CF Monterrey | - | CF América | 3:2 (2:0) | ||
| H (Match allé): 18.11.2020 18:00 | R (match retour): 21.11.2020 16:00 | vainqueur: CF Monterrey | ||||
| H (Match allé) | Pumas UNAM | - | Atlas Guadalajara | 0:2 (0:1) | ||
| R (match retour) | Atlas Guadalajara | - | Pumas UNAM | 0:2 (0:1) | ||
| H (Match allé): 18.11.2020 19:00 | R (match retour): 21.11.2020 16:00 | |||||
| H (Match allé) | Club León | - | Cruz Azul | 0:1 (0:0) | ||
| R (match retour) | Cruz Azul | - | Club León | 2:2 (2:1) | ||
| H (Match allé): 18.11.2020 22:45 | R (match retour): 21.11.2020 16:00 | vainqueur: Cruz Azul | ||||
| H (Match allé) | UANL Tigres | - | Deportivo Guadalajara | 0:1 (0:1) | ||
| R (match retour) | Deportivo Guadalajara | - | UANL Tigres | 4:1 (1:1) | ||
| H (Match allé): 19.11.2020 17:30 | R (match retour): 22.11.2020 16:00 | vainqueur: Deportivo Guadalajara | ||||
