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| 24.02.2022 | 20:00 | EVV | - | VV Gemert | 2:2 (1:1) | |
| 20:15 | VV Hoogland | - | VV UNA | 2:2 (1:1) | ||
| 27.02.2022 | 14:00 | HVV Hollandia | - | VV Dongen | 0:2 (0:2) | |
| 14:00 | Quick Den Haag | - | Blauw Geel '38 | 3:2 (3:0) | ||
| 14:00 | RKVV DEM | - | Unitas Gorinchem | 1:2 (0:0) | ||
| 14:00 | JOS Watergraafsmeer | - | OFC Oostzaan | 5:4 (0:2) | ||
| 14:30 | HSC'21 | - | ADO '20 | 3:1 (1:0) | ||
| 14:30 | RKSV Groene Ster | - | USV Hercules | 2:1 (1:1) | ||
| 16.03.2022 | 19:30 | OSS '20 | - | RKVV Westlandia | 2:1 (1:0) |
| # | Équipe | M. | G. | N. | P. | Buts | Diff. | Pts. | |
|---|---|---|---|---|---|---|---|---|---|
| 1 |
|
OFC Oostzaan | 16 | 12 | 1 | 3 | 40:23 | 17 | 37 |
| 2 |
|
VV Gemert | 16 | 8 | 7 | 1 | 36:24 | 12 | 31 |
| 3 |
|
RKSV Groene Ster | 16 | 8 | 5 | 3 | 24:20 | 4 | 29 |
| 4 |
|
Unitas Gorinchem | 16 | 9 | 1 | 6 | 25:26 | -1 | 28 |
| 5 |
|
VV UNA | 16 | 8 | 3 | 5 | 28:25 | 3 | 27 |
| 6 |
|
VV Dongen | 16 | 6 | 7 | 3 | 24:18 | 6 | 25 |
| 7 |
|
OSS '20 | 16 | 8 | 2 | 6 | 29:25 | 4 | 25 |
| 8 |
|
ADO '20 | 16 | 8 | 1 | 7 | 29:26 | 3 | 25 |
| 9 |
|
USV Hercules | 16 | 7 | 3 | 6 | 30:23 | 7 | 24 |
| 10 |
|
Blauw Geel '38 | 16 | 6 | 2 | 8 | 29:29 | 0 | 20 |
| 11 |
|
Quick Den Haag | 16 | 6 | 2 | 8 | 18:20 | -2 | 20 |
| 12 |
|
JOS Watergraafsmeer | 16 | 6 | 3 | 7 | 32:31 | 1 | 19 |
| 13 |
|
HSC'21 | 16 | 5 | 2 | 9 | 24:23 | 1 | 17 |
| 14 |
|
VV Hoogland | 16 | 4 | 4 | 8 | 17:31 | -14 | 16 |
| 15 |
|
HVV Hollandia | 16 | 4 | 3 | 9 | 14:22 | -8 | 15 |
| 16 |
|
RKVV Westlandia | 16 | 3 | 5 | 8 | 18:25 | -7 | 14 |
| 17 |
|
EVV | 16 | 2 | 8 | 6 | 12:20 | -8 | 14 |
| 18 |
|
RKVV DEM | 16 | 3 | 3 | 10 | 11:29 | -18 | 12 |
| Promotion | |
| Relégation | |
| Relégation |
