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| 18.04.2022 | 14:00 | VV Hoogland | - | HSC'21 | 0:1 (0:0) | |
| 14:00 | VV Dongen | - | OFC Oostzaan | 1:1 (0:1) | ||
| 14:00 | HVV Hollandia | - | JOS Watergraafsmeer | 0:1 (0:0) | ||
| 14:00 | Quick Den Haag | - | OSS '20 | 0:2 (0:0) | ||
| 14:00 | Blauw Geel '38 | - | RKVV Westlandia | 4:0 (2:0) | ||
| 14:00 | RKVV DEM | - | RKSV Groene Ster | 1:0 (0:0) | ||
| 14:00 | Unitas Gorinchem | - | USV Hercules | 1:0 (0:0) | ||
| 14:00 | VV Gemert | - | VV UNA | 1:2 (0:2) | ||
| 14:30 | EVV | - | ADO '20 | 1:1 (0:1) |
| # | Équipe | M. | G. | N. | P. | Buts | Diff. | Pts. | |
|---|---|---|---|---|---|---|---|---|---|
| 1 |
|
VV Gemert | 26 | 15 | 9 | 2 | 62:39 | 23 | 54 |
| 2 |
|
OFC Oostzaan | 26 | 14 | 4 | 8 | 53:44 | 9 | 46 |
| 3 |
|
VV Dongen | 26 | 11 | 10 | 5 | 44:32 | 12 | 43 |
| 4 |
|
RKSV Groene Ster | 26 | 12 | 7 | 7 | 38:33 | 5 | 43 |
| 5 |
|
USV Hercules | 26 | 13 | 3 | 10 | 50:35 | 15 | 42 |
| 6 |
|
OSS '20 | 26 | 13 | 4 | 9 | 49:36 | 13 | 42 |
| 7 |
|
ADO '20 | 26 | 12 | 5 | 9 | 44:35 | 9 | 41 |
| 8 |
|
VV UNA | 26 | 12 | 4 | 10 | 48:42 | 6 | 40 |
| 9 |
|
Unitas Gorinchem | 26 | 11 | 4 | 11 | 33:45 | -12 | 37 |
| 10 |
|
Blauw Geel '38 | 26 | 11 | 3 | 12 | 47:41 | 6 | 36 |
| 11 |
|
Quick Den Haag | 26 | 11 | 3 | 12 | 36:34 | 2 | 36 |
| 12 |
|
HSC'21 | 26 | 10 | 3 | 13 | 40:36 | 4 | 33 |
| 13 |
|
JOS Watergraafsmeer | 26 | 10 | 4 | 12 | 44:48 | -4 | 32 |
| 14 |
|
RKVV DEM | 26 | 8 | 5 | 13 | 25:40 | -15 | 29 |
| 15 |
|
EVV | 26 | 6 | 10 | 10 | 25:40 | -15 | 28 |
| 16 |
|
HVV Hollandia | 26 | 8 | 3 | 15 | 29:40 | -11 | 27 |
| 17 |
|
VV Hoogland | 26 | 7 | 4 | 15 | 26:51 | -25 | 25 |
| 18 |
|
RKVV Westlandia | 26 | 4 | 7 | 15 | 22:44 | -22 | 19 |
| Promotion | |
| Relégation | |
| Relégation |
