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| 02.01.2021 | 18:45 | Helmond Sport | - | FC Dordrecht | 5:2 (1:2) | |
| 21:00 | Almere City FC | - | De Graafschap | 1:0 (0:0) | ||
| 03.01.2021 | 12:15 | SBV Excelsior | - | NAC Breda | 0:3 (0:2) | |
| 14:30 | FC Eindhoven | - | SC Cambuur | 2:5 (1:5) | ||
| 16:45 | Telstar | - | NEC Nijmegen | 5:2 (3:0) | ||
| 20:00 | FC Volendam | - | MVV | 0:1 (0:1) | ||
| 04.01.2021 | 18:45 | AZ Alkmaar (J) | - | Roda JC Kerkrade | 0:1 (0:0) | |
| 21:00 | FC Utrecht (J) | - | FC Den Bosch | 3:1 (2:0) | ||
| 05.01.2021 | 18:45 | Jong PSV | - | Go Ahead Eagles | 2:3 (0:2) | |
| 21:00 | TOP Oss | - | Jong Ajax | 1:0 (1:0) |
| » Classement | équipe recevante | à l'extérieur | Premier tour | Second tour |
| # | Équipe | M. | G. | N. | P. | Buts | Diff. | Pts. | |
|---|---|---|---|---|---|---|---|---|---|
| 1 |
|
SC Cambuur | 18 | 15 | 1 | 2 | 58:17 | 41 | 46 |
| 2 |
|
Almere City FC | 18 | 13 | 4 | 1 | 42:22 | 20 | 43 |
| 3 |
|
NAC Breda | 18 | 11 | 2 | 5 | 33:15 | 18 | 35 |
| 4 |
|
De Graafschap | 18 | 11 | 2 | 5 | 36:28 | 8 | 35 |
| 5 |
|
NEC Nijmegen | 18 | 9 | 4 | 5 | 33:23 | 10 | 31 |
| 6 |
|
FC Volendam | 18 | 8 | 6 | 4 | 43:23 | 20 | 30 |
| 7 |
|
Go Ahead Eagles | 18 | 8 | 5 | 5 | 23:15 | 8 | 29 |
| 8 |
|
Telstar | 18 | 8 | 4 | 6 | 34:26 | 8 | 28 |
| 9 |
|
FC Eindhoven | 18 | 7 | 5 | 6 | 32:34 | -2 | 26 |
| 10 |
|
Roda JC Kerkrade | 18 | 6 | 7 | 5 | 27:24 | 3 | 25 |
| 11 |
|
TOP Oss | 18 | 7 | 4 | 7 | 16:23 | -7 | 25 |
| 12 |
|
Jong Ajax | 18 | 6 | 4 | 8 | 31:35 | -4 | 22 |
| 13 |
|
FC Utrecht (J) | 18 | 7 | 1 | 10 | 28:35 | -7 | 22 |
| 14 |
|
SBV Excelsior | 18 | 6 | 2 | 10 | 32:32 | 0 | 20 |
| 15 |
|
Helmond Sport | 18 | 5 | 5 | 8 | 22:30 | -8 | 20 |
| 16 |
|
Jong PSV | 18 | 4 | 4 | 10 | 27:36 | -9 | 16 |
| 17 |
|
MVV | 18 | 4 | 4 | 10 | 22:42 | -20 | 16 |
| 18 |
|
AZ Alkmaar (J) | 18 | 3 | 3 | 12 | 23:47 | -24 | 12 |
| 19 |
|
FC Den Bosch | 18 | 2 | 5 | 11 | 18:41 | -23 | 11 |
| 20 |
|
FC Dordrecht | 18 | 3 | 2 | 13 | 16:48 | -32 | 11 |
| Promotion | |
| Play-off |
