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| 04.11.2005 | 20:00 | SC Cambuur | - | FC Dordrecht | 0:0 (0:0) | |
| 20:00 | AGOVV | - | FC Zwolle | 1:4 (0:1) | ||
| 20:00 | FC Emmen | - | FC Volendam | 4:1 (2:1) | ||
| 20:00 | FC Omniworld | - | MVV | 1:3 (0:2) | ||
| 20:00 | Fortuna Sittard | - | BV Veendam | 1:3 (1:1) | ||
| 20:00 | Go Ahead Eagles | - | SBV Excelsior | 1:0 (0:0) | ||
| 20:00 | Helmond Sport | - | De Graafschap | 1:2 (0:2) | ||
| 20:00 | TOP Oss | - | HFC Haarlem | 3:1 (2:1) | ||
| 20:00 | VVV-Venlo | - | FC Eindhoven | 0:1 (0:0) | ||
| 06.11.2005 | 14:30 | Stormvogels Telstar | - | FC Den Bosch | 2:0 (0:0) |
| » Classement | équipe recevante | à l'extérieur | Premier tour | Second tour |
| # | Équipe | M. | G. | N. | P. | Buts | Diff. | Pts. | |
|---|---|---|---|---|---|---|---|---|---|
| 1 |
|
VVV-Venlo | 16 | 11 | 3 | 2 | 28:8 | 20 | 36 |
| 2 |
|
SBV Excelsior | 16 | 10 | 3 | 3 | 28:11 | 17 | 33 |
| 3 |
|
FC Volendam | 16 | 10 | 3 | 3 | 28:15 | 13 | 33 |
| 4 |
|
FC Emmen | 16 | 10 | 2 | 4 | 35:19 | 16 | 32 |
| 5 |
|
FC Zwolle | 16 | 9 | 4 | 3 | 29:17 | 12 | 31 |
| 6 |
|
FC Den Bosch | 16 | 8 | 4 | 4 | 30:22 | 8 | 28 |
| 7 |
|
Helmond Sport | 16 | 8 | 3 | 5 | 26:25 | 1 | 27 |
| 8 |
|
MVV | 16 | 7 | 5 | 4 | 26:19 | 7 | 26 |
| 9 |
|
BV Veendam | 16 | 6 | 4 | 6 | 18:18 | 0 | 22 |
| 10 |
|
De Graafschap | 16 | 6 | 4 | 6 | 16:19 | -3 | 22 |
| 11 |
|
FC Dordrecht | 16 | 5 | 6 | 5 | 21:19 | 2 | 21 |
| 12 |
|
AGOVV | 16 | 6 | 2 | 8 | 32:31 | 1 | 20 |
| 13 |
|
Go Ahead Eagles | 16 | 4 | 6 | 6 | 22:27 | -5 | 18 |
| 14 |
|
TOP Oss | 16 | 4 | 5 | 7 | 20:29 | -9 | 17 |
| 15 |
|
Stormvogels Telstar | 16 | 3 | 7 | 6 | 16:22 | -6 | 16 |
| 16 |
|
FC Eindhoven | 16 | 4 | 3 | 9 | 24:28 | -4 | 15 |
| 17 |
|
HFC Haarlem | 16 | 3 | 3 | 10 | 16:37 | -21 | 12 |
| 18 |
|
SC Cambuur | 16 | 2 | 8 | 6 | 16:21 | -5 | 11 |
| 19 |
|
FC Omniworld | 16 | 3 | 1 | 12 | 19:39 | -20 | 10 |
| 20 |
|
Fortuna Sittard | 16 | 1 | 4 | 11 | 15:39 | -24 | 7 |
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