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| 27.01.2006 | 20:00 | HFC Haarlem | - | Go Ahead Eagles | 5:0 (2:0) | |
| 20:00 | FC Zwolle | - | Stormvogels Telstar | 2:2 (0:2) | ||
| 20:00 | FC Volendam | - | FC Eindhoven | 1:0 (0:0) | ||
| 20:00 | FC Omniworld | - | Fortuna Sittard | 1:1 (1:0) | ||
| 20:00 | FC Dordrecht | - | BV Veendam | 1:2 (1:0) | ||
| 20:00 | TOP Oss | - | VVV-Venlo | 1:0 (1:0) | ||
| 20:00 | Helmond Sport | - | SC Cambuur | 1:2 (1:1) | ||
| 13.02.2006 | 20:00 | MVV | - | SBV Excelsior | 0:0 (0:0) | |
| 20.02.2006 | 20:00 | De Graafschap | - | FC Den Bosch | 1:0 (0:0) | |
| 20:00 | FC Emmen | - | AGOVV | 3:0 (1:0) |
| » Classement | équipe recevante | à l'extérieur | Premier tour | Second tour |
| # | Équipe | M. | G. | N. | P. | Buts | Diff. | Pts. | |
|---|---|---|---|---|---|---|---|---|---|
| 1 |
|
SBV Excelsior | 27 | 16 | 6 | 5 | 53:17 | 36 | 54 |
| 2 |
|
VVV-Venlo | 27 | 15 | 7 | 5 | 39:15 | 24 | 52 |
| 3 |
|
FC Emmen | 27 | 15 | 4 | 8 | 52:32 | 20 | 49 |
| 4 |
|
FC Volendam | 27 | 14 | 7 | 6 | 41:29 | 12 | 49 |
| 5 |
|
FC Den Bosch | 27 | 12 | 9 | 6 | 49:38 | 11 | 45 |
| 6 |
|
Helmond Sport | 27 | 13 | 5 | 9 | 43:42 | 1 | 44 |
| 7 |
|
De Graafschap | 27 | 12 | 6 | 9 | 40:32 | 8 | 42 |
| 8 |
|
FC Zwolle | 27 | 11 | 8 | 8 | 45:38 | 7 | 41 |
| 9 |
|
MVV | 27 | 10 | 9 | 8 | 38:34 | 4 | 39 |
| 10 |
|
HFC Haarlem | 27 | 11 | 6 | 10 | 42:45 | -3 | 39 |
| 11 |
|
BV Veendam | 27 | 10 | 6 | 11 | 40:41 | -1 | 36 |
| 12 |
|
AGOVV | 27 | 11 | 3 | 13 | 46:48 | -2 | 36 |
| 13 |
|
TOP Oss | 27 | 8 | 10 | 9 | 33:41 | -8 | 34 |
| 14 |
|
FC Dordrecht | 27 | 8 | 9 | 10 | 31:32 | -1 | 33 |
| 15 |
|
Stormvogels Telstar | 27 | 6 | 10 | 11 | 24:38 | -14 | 28 |
| 16 |
|
Go Ahead Eagles | 27 | 6 | 9 | 12 | 31:49 | -18 | 27 |
| 17 |
|
FC Omniworld | 27 | 7 | 6 | 14 | 36:57 | -21 | 27 |
| 18 |
|
SC Cambuur | 27 | 6 | 10 | 11 | 29:40 | -11 | 25 |
| 19 |
|
FC Eindhoven | 27 | 6 | 5 | 16 | 35:46 | -11 | 23 |
| 20 |
|
Fortuna Sittard | 27 | 1 | 9 | 17 | 26:59 | -33 | 12 |
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