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| 17.02.2006 | 20:00 | Helmond Sport | - | FC Omniworld | 3:1 (2:1) | |
| 20:00 | Stormvogels Telstar | - | De Graafschap | 0:1 (0:1) | ||
| 20:00 | AGOVV | - | FC Eindhoven | 1:4 (1:3) | ||
| 20:00 | SC Cambuur | - | FC Zwolle | 0:0 (0:0) | ||
| 20:00 | FC Emmen | - | TOP Oss | 1:2 (1:1) | ||
| 20:00 | SBV Excelsior | - | FC Dordrecht | 0:1 (0:0) | ||
| 20:00 | FC Den Bosch | - | BV Veendam | 3:1 (2:0) | ||
| 20:00 | VVV-Venlo | - | MVV | 1:3 (0:1) | ||
| 20:00 | Go Ahead Eagles | - | FC Volendam | 1:2 (1:0) | ||
| 20:15 | Fortuna Sittard | - | HFC Haarlem | 0:3 (0:2) |
| » Classement | équipe recevante | à l'extérieur | Premier tour | Second tour |
| # | Équipe | M. | G. | N. | P. | Buts | Diff. | Pts. | |
|---|---|---|---|---|---|---|---|---|---|
| 1 |
|
SBV Excelsior | 30 | 17 | 7 | 6 | 57:19 | 38 | 58 |
| 2 |
|
VVV-Venlo | 30 | 16 | 7 | 7 | 41:20 | 21 | 55 |
| 3 |
|
FC Emmen | 30 | 16 | 5 | 9 | 58:38 | 20 | 53 |
| 4 |
|
FC Volendam | 30 | 15 | 8 | 7 | 43:31 | 12 | 53 |
| 5 |
|
FC Den Bosch | 30 | 14 | 10 | 6 | 55:41 | 14 | 52 |
| 6 |
|
HFC Haarlem | 30 | 14 | 6 | 10 | 51:46 | 5 | 48 |
| 7 |
|
Helmond Sport | 30 | 14 | 6 | 10 | 48:46 | 2 | 48 |
| 8 |
|
De Graafschap | 30 | 13 | 7 | 10 | 44:38 | 6 | 46 |
| 9 |
|
FC Zwolle | 30 | 12 | 9 | 9 | 48:39 | 9 | 45 |
| 10 |
|
MVV | 30 | 11 | 10 | 9 | 45:40 | 5 | 43 |
| 11 |
|
FC Dordrecht | 30 | 10 | 10 | 10 | 37:35 | 2 | 40 |
| 12 |
|
BV Veendam | 30 | 11 | 7 | 12 | 44:46 | -2 | 40 |
| 13 |
|
AGOVV | 30 | 12 | 4 | 14 | 50:54 | -4 | 40 |
| 14 |
|
TOP Oss | 30 | 10 | 10 | 10 | 37:44 | -7 | 40 |
| 15 |
|
Stormvogels Telstar | 30 | 7 | 10 | 13 | 29:46 | -17 | 31 |
| 16 |
|
SC Cambuur | 30 | 7 | 11 | 12 | 30:41 | -11 | 29 |
| 17 |
|
Go Ahead Eagles | 30 | 6 | 11 | 13 | 35:54 | -19 | 29 |
| 18 |
|
FC Omniworld | 30 | 7 | 6 | 17 | 40:65 | -25 | 27 |
| 19 |
|
FC Eindhoven | 30 | 7 | 5 | 18 | 41:52 | -11 | 26 |
| 20 |
|
Fortuna Sittard | 30 | 2 | 9 | 19 | 28:66 | -38 | 15 |
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