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| 03.03.2006 | 20:00 | FC Emmen | - | HFC Haarlem | 0:2 (0:2) | |
| 20:00 | SC Cambuur | - | MVV | 3:0 (2:0) | ||
| 20:00 | Fortuna Sittard | - | De Graafschap | 1:2 (1:1) | ||
| 20:00 | Helmond Sport | - | FC Zwolle | 2:1 (0:0) | ||
| 20:00 | FC Omniworld | - | TOP Oss | 0:4 (0:1) | ||
| 20:00 | Stormvogels Telstar | - | FC Dordrecht | 1:1 (0:1) | ||
| 20.03.2006 | 20:00 | AGOVV | - | FC Den Bosch | 3:0 (0:0) | |
| 20:00 | SBV Excelsior | - | FC Eindhoven | 1:0 (1:0) | ||
| 20:00 | Go Ahead Eagles | - | BV Veendam | 4:0 (1:0) | ||
| 20:00 | VVV-Venlo | - | FC Volendam | 3:2 (1:1) |
| » Classement | équipe recevante | à l'extérieur | Premier tour | Second tour |
| # | Équipe | M. | G. | N. | P. | Buts | Diff. | Pts. | |
|---|---|---|---|---|---|---|---|---|---|
| 1 |
|
SBV Excelsior | 32 | 18 | 7 | 7 | 59:21 | 38 | 61 |
| 2 |
|
VVV-Venlo | 32 | 17 | 7 | 8 | 44:24 | 20 | 58 |
| 3 |
|
FC Volendam | 32 | 15 | 9 | 8 | 45:34 | 11 | 54 |
| 4 |
|
FC Emmen | 32 | 16 | 5 | 11 | 58:41 | 17 | 53 |
| 5 |
|
FC Den Bosch | 32 | 14 | 10 | 8 | 56:46 | 10 | 52 |
| 6 |
|
De Graafschap | 32 | 15 | 7 | 10 | 48:39 | 9 | 52 |
| 7 |
|
HFC Haarlem | 32 | 15 | 7 | 10 | 53:46 | 7 | 52 |
| 8 |
|
Helmond Sport | 32 | 15 | 6 | 11 | 51:49 | 2 | 51 |
| 9 |
|
FC Zwolle | 32 | 13 | 9 | 10 | 50:41 | 9 | 48 |
| 10 |
|
MVV | 32 | 12 | 10 | 10 | 48:44 | 4 | 46 |
| 11 |
|
AGOVV | 32 | 14 | 4 | 14 | 56:55 | 1 | 46 |
| 12 |
|
TOP Oss | 32 | 12 | 10 | 10 | 43:45 | -2 | 46 |
| 13 |
|
FC Dordrecht | 32 | 11 | 11 | 10 | 43:37 | 6 | 44 |
| 14 |
|
BV Veendam | 32 | 12 | 7 | 13 | 46:51 | -5 | 43 |
| 15 |
|
SC Cambuur | 32 | 8 | 12 | 12 | 33:41 | -8 | 33 |
| 16 |
|
Stormvogels Telstar | 32 | 7 | 12 | 13 | 30:47 | -17 | 33 |
| 17 |
|
Go Ahead Eagles | 32 | 7 | 11 | 14 | 40:59 | -19 | 32 |
| 18 |
|
FC Eindhoven | 32 | 8 | 5 | 19 | 43:54 | -11 | 29 |
| 19 |
|
FC Omniworld | 32 | 7 | 6 | 19 | 41:72 | -31 | 27 |
| 20 |
|
Fortuna Sittard | 32 | 2 | 9 | 21 | 30:71 | -41 | 15 |
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