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| 22.02.2008 | 20:00 | BV Veendam | - | SC Cambuur | 4:4 (1:0) | |
| 20:00 | FC Emmen | - | TOP Oss | 2:1 (0:1) | ||
| 20:00 | FC Dordrecht | - | HFC Haarlem | 1:1 (0:1) | ||
| 20:00 | Helmond Sport | - | RBC Roosendaal | 2:0 (0:0) | ||
| 20:00 | RKC Waalwijk | - | FC Volendam | 2:3 (0:0) | ||
| 20:00 | FC Zwolle | - | MVV | 7:0 (2:0) | ||
| 20:00 | FC Den Bosch | - | Go Ahead Eagles | 3:1 (2:1) | ||
| 20:00 | Fortuna Sittard | - | FC Eindhoven | 3:0 (1:0) | ||
| 20:00 | ADO Den Haag | - | FC Omniworld | 1:1 (1:1) | ||
| 20:30 | Stormvogels Telstar | - | AGOVV | 4:4 (1:2) |
| » Classement | équipe recevante | à l'extérieur | Premier tour | Second tour |
| # | Équipe | M. | G. | N. | P. | Buts | Diff. | Pts. | |
|---|---|---|---|---|---|---|---|---|---|
| 1 |
|
RKC Waalwijk | 29 | 16 | 10 | 3 | 69:36 | 33 | 58 |
| 2 |
|
FC Zwolle | 29 | 15 | 10 | 4 | 60:32 | 28 | 55 |
| 3 |
|
FC Volendam | 29 | 14 | 11 | 4 | 66:38 | 28 | 53 |
| 4 |
|
FC Den Bosch | 29 | 16 | 5 | 8 | 48:34 | 14 | 53 |
| 5 |
|
MVV | 29 | 13 | 7 | 9 | 45:42 | 3 | 46 |
| 6 |
|
ADO Den Haag | 29 | 12 | 8 | 9 | 47:42 | 5 | 44 |
| 7 |
|
Helmond Sport | 29 | 13 | 5 | 11 | 42:38 | 4 | 44 |
| 8 |
|
Go Ahead Eagles | 29 | 14 | 1 | 14 | 48:51 | -3 | 43 |
| 9 |
|
RBC Roosendaal | 29 | 10 | 10 | 9 | 37:36 | 1 | 40 |
| 10 |
|
TOP Oss | 29 | 10 | 9 | 10 | 45:50 | -5 | 39 |
| 11 |
|
FC Emmen | 29 | 9 | 10 | 10 | 44:56 | -12 | 37 |
| 12 |
|
FC Dordrecht | 29 | 9 | 9 | 11 | 51:42 | 9 | 36 |
| 13 |
|
Stormvogels Telstar | 29 | 10 | 4 | 15 | 32:42 | -10 | 34 |
| 14 |
|
FC Omniworld | 29 | 6 | 13 | 10 | 45:40 | 5 | 31 |
| 15 |
|
BV Veendam | 29 | 7 | 13 | 9 | 47:55 | -8 | 31 |
| 16 |
|
Fortuna Sittard | 29 | 7 | 8 | 14 | 35:47 | -12 | 29 |
| 17 |
|
AGOVV | 29 | 9 | 5 | 15 | 47:72 | -25 | 29 |
| 18 |
|
HFC Haarlem | 29 | 5 | 12 | 12 | 34:44 | -10 | 27 |
| 19 |
|
FC Eindhoven | 29 | 7 | 6 | 16 | 38:65 | -27 | 27 |
| 20 |
|
SC Cambuur | 29 | 6 | 8 | 15 | 38:56 | -18 | 26 |
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