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| H (Match allé) | SP Tre Fiori | - | SC Faetano | 1:1 (0:0) | ||
| R (match retour) | SC Faetano | - | SP Tre Fiori | 1:1 (0:0) | ||
| H (Match allé): 11.05.2022 20:45 | R (match retour): 15.05.2022 15:00 | |||||
| H (Match allé) | SS Virtus | - | SS Pennarossa | 0:1 (0:0) | ||
| R (match retour) | SS Pennarossa | - | SS Virtus | 1:1 (0:1) | ||
| H (Match allé): 11.05.2022 20:45 | R (match retour): 15.05.2022 15:00 | vainqueur: SS Pennarossa | ||||
| H (Match allé) | SP Tre Penne | - | AC Libertas | 2:0 (0:0) | ||
| R (match retour) | AC Libertas | - | SP Tre Penne | 1:0 (1:0) | ||
| H (Match allé): 11.05.2022 20:45 | R (match retour): 15.05.2022 15:00 | vainqueur: SP Tre Penne | ||||
| H (Match allé) | SP La Fiorita | - | FC Fiorentino | 0:1 (0:0) | ||
| R (match retour) | FC Fiorentino | - | SP La Fiorita | 0:2 (0:1) | ||
| H (Match allé): 11.05.2022 20:45 | R (match retour): 15.05.2022 15:00 | vainqueur: SP La Fiorita | ||||
