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|
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| 18.09.2021 | 18:30 | Godoy Cruz | - | Sarmiento de Junín | 1:1 (0:0) | |
| 20:45 | Vélez Sarsfield | - | Aldosivi | 3:2 (1:1) | ||
| 23:00 | Racing Club | - | Talleres de Córdoba | 1:2 (1:1) | ||
| 19.09.2021 | 01:15 | Atlético Tucumán | - | Boca Juniors | 1:2 (0:2) | |
| 18:30 | Patronato de Paraná | - | Estudiantes | 1:2 (1:2) | ||
| 20:45 | Colón de Santa Fe | - | Central Córdoba SdE | 1:0 (1:0) | ||
| 20:45 | Platense | - | Argentinos Juniors | 0:0 (0:0) | ||
| 23:00 | Huracán | - | Independiente | 0:1 (0:1) | ||
| 20.09.2021 | 01:15 | River Plate | - | Arsenal de Sarandí | 1:0 (0:0) | |
| 18:30 | Gimnasia de La Plata | - | Unión de Santa Fe | 1:0 (0:0) | ||
| 20:45 | Lanús | - | Newell's Old Boys | 1:2 (1:2) | ||
| 23:00 | Rosario Central | - | San Lorenzo | 1:0 (0:0) | ||
| 21.09.2021 | 01:15 | Defensa y Justicia | - | Banfield | 0:0 (0:0) |
| » Classement | équipe recevante | à l'extérieur | Premier tour | Second tour |
| # | Équipe | M. | G. | N. | P. | Buts | Diff. | Pts. | |
|---|---|---|---|---|---|---|---|---|---|
| 1 |
|
Talleres de Córdoba | 12 | 8 | 2 | 2 | 18:9 | 9 | 26 |
| 2 |
|
River Plate | 12 | 7 | 3 | 2 | 23:9 | 14 | 24 |
| 3 |
|
Estudiantes | 12 | 7 | 2 | 3 | 20:11 | 9 | 23 |
| 4 |
|
Lanús | 12 | 7 | 2 | 3 | 22:18 | 4 | 23 |
| 5 |
|
Independiente | 12 | 6 | 4 | 2 | 12:6 | 6 | 22 |
| 6 |
|
Colón de Santa Fe | 12 | 5 | 4 | 3 | 10:14 | -4 | 19 |
| 7 |
|
Racing Club | 12 | 4 | 6 | 2 | 10:4 | 6 | 18 |
| 8 |
|
Boca Juniors | 12 | 4 | 6 | 2 | 10:8 | 2 | 18 |
| 9 |
|
Vélez Sarsfield | 12 | 4 | 5 | 3 | 16:8 | 8 | 17 |
| 10 |
|
Godoy Cruz | 12 | 5 | 2 | 5 | 19:17 | 2 | 17 |
| 11 |
|
Rosario Central | 12 | 5 | 1 | 6 | 17:14 | 3 | 16 |
| 12 |
|
Defensa y Justicia | 12 | 3 | 6 | 3 | 12:10 | 2 | 15 |
| 13 |
|
Argentinos Juniors | 12 | 3 | 6 | 3 | 9:8 | 1 | 15 |
| 14 |
|
Newell's Old Boys | 12 | 4 | 3 | 5 | 14:18 | -4 | 15 |
| 15 |
|
Atlético Tucumán | 12 | 4 | 3 | 5 | 12:16 | -4 | 15 |
| 16 |
|
Patronato de Paraná | 12 | 3 | 5 | 4 | 10:12 | -2 | 14 |
| 17 |
|
Gimnasia de La Plata | 12 | 3 | 5 | 4 | 8:13 | -5 | 14 |
| 18 |
|
Huracán | 12 | 2 | 7 | 3 | 8:8 | 0 | 13 |
| 19 |
|
Sarmiento de Junín | 12 | 3 | 4 | 5 | 11:15 | -4 | 13 |
| 20 |
|
San Lorenzo | 12 | 3 | 4 | 5 | 10:14 | -4 | 13 |
| 21 |
|
Aldosivi | 12 | 4 | 1 | 7 | 14:21 | -7 | 13 |
| 22 |
|
Unión de Santa Fe | 12 | 3 | 3 | 6 | 10:17 | -7 | 12 |
| 23 |
|
Platense | 12 | 2 | 5 | 5 | 14:17 | -3 | 11 |
| 24 |
|
Central Córdoba SdE | 12 | 2 | 5 | 5 | 12:15 | -3 | 11 |
| 25 |
|
Banfield | 12 | 1 | 7 | 4 | 8:13 | -5 | 10 |
| 26 |
|
Arsenal de Sarandí | 12 | 1 | 5 | 6 | 5:19 | -14 | 8 |
| Copa Libertadores | |
| Copa Sudamericana | |
| Copa Libertadores | |
| Copa Libertadores | |
| Copa Sudamericana | |
| Copa Sudamericana | |
| Copa Sudamericana |
