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| 09.10.2021 | 01:00 | Gimnasia y Esgrima (CdU) | - | Crucero del Norte | 1:1 (0:0) | |
| 20:30 | Gimnasia y Tiro de Salta | - | Sarmiento de Resistencia | 2:2 (1:0) | ||
| 10.10.2021 | 16:00 | Sportivo Las Parejas | - | Defensores Belgrano (VR) | 3:1 (2:1) | |
| 16:00 | Boca Unidos | - | Defensores de Pronunciamiento | 1:2 (1:0) | ||
| 20:00 | Racing de Córdoba | - | Central Norte | 1:1 (0:0) | ||
| 20:00 | Douglas Haig | - | Unión de Sunchales | 3:0 (3:0) | ||
| 20:00 | Juventud Unida de Gualeguaychú | - | Belgrano de San Francisco | 1:0 (0:0) |
| » Classement | équipe recevante | à l'extérieur | Premier tour | Second tour |
| # | Équipe | M. | G. | N. | P. | Buts | Diff. | Pts. | |
|---|---|---|---|---|---|---|---|---|---|
| 1 |
|
Racing de Córdoba | 26 | 15 | 8 | 3 | 42:16 | 26 | 53 |
| 2 |
|
Gimnasia y Tiro de Salta | 25 | 14 | 8 | 3 | 33:18 | 15 | 50 |
| 3 |
|
Central Norte | 25 | 10 | 12 | 3 | 35:22 | 13 | 42 |
| 4 |
|
Chaco For Ever | 25 | 10 | 10 | 5 | 29:19 | 10 | 40 |
| 5 |
|
Sportivo Las Parejas | 25 | 9 | 8 | 8 | 29:25 | 4 | 35 |
| 6 |
|
Defensores de Pronunciamiento | 25 | 9 | 8 | 8 | 28:29 | -1 | 35 |
| 7 |
|
Juventud Unida de Gualeguaychú | 25 | 9 | 7 | 9 | 26:30 | -4 | 34 |
| 8 |
|
Defensores Belgrano (VR) | 25 | 9 | 5 | 11 | 33:38 | -5 | 32 |
| 9 |
|
Sarmiento de Resistencia | 26 | 7 | 9 | 10 | 35:40 | -5 | 30 |
| 10 |
|
Unión de Sunchales | 25 | 7 | 9 | 9 | 26:32 | -6 | 30 |
| 11 |
|
Boca Unidos | 25 | 6 | 11 | 8 | 32:33 | -1 | 29 |
| 12 |
|
Gimnasia y Esgrima (CdU) | 25 | 7 | 5 | 13 | 20:34 | -14 | 26 |
| 13 |
|
Douglas Haig | 25 | 7 | 4 | 14 | 19:24 | -5 | 25 |
| 14 |
|
Belgrano de San Francisco | 26 | 5 | 10 | 11 | 24:33 | -9 | 25 |
| 15 |
|
Crucero del Norte | 25 | 4 | 8 | 13 | 17:35 | -18 | 20 |
| Play-off | |
| Prochaine phase |
