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| 29.11.2021 | 19:30 | KAS Eupen II | - | KV Oostende II | 3:0 (1:0) | |
| 19:30 | SK Beveren II | - | Lommel SK II | 3:0 | ||
| 19:30 | KV Kortrijk II | - | RFC Seraing II | 3:2 | ||
| 20:00 | K Beerschot VA II | - | Royal Excel Mouscron II | 2:2 | ||
| 20:00 | KVC Westerlo II | - | Lierse Kempenzonen II | 2:2 (1:2) | ||
| 20:30 | RWDM Brussels FC II | - | Excelsior Virton II | 5:0 | ||
| 28.03.2022 | 20:00 | Union St. Gilloise II | - | SK Deinze II | 2:0 |
| » Classement | équipe recevante | à l'extérieur | Premier tour | Second tour |
| # | Équipe | M. | G. | N. | P. | Buts | Diff. | Pts. | |
|---|---|---|---|---|---|---|---|---|---|
| 1 |
|
KAS Eupen II | 12 | 9 | 1 | 2 | 29:13 | 16 | 28 |
| 2 |
|
K Beerschot VA II | 12 | 7 | 3 | 2 | 26:13 | 13 | 24 |
| 3 |
|
KV Oostende II | 12 | 6 | 5 | 1 | 29:13 | 16 | 23 |
| 4 |
|
RWDM Brussels FC II | 12 | 7 | 1 | 4 | 32:22 | 10 | 22 |
| 5 |
|
Excelsior Virton II | 12 | 6 | 2 | 4 | 27:33 | -6 | 20 |
| 6 |
|
SK Beveren II | 12 | 6 | 1 | 5 | 20:11 | 9 | 19 |
| 7 |
|
Royal Excel Mouscron II | 12 | 5 | 2 | 5 | 19:12 | 7 | 17 |
| 8 |
|
Union St. Gilloise II | 12 | 5 | 2 | 5 | 14:10 | 4 | 17 |
| 9 |
|
KVC Westerlo II | 12 | 5 | 2 | 5 | 17:18 | -1 | 17 |
| 10 |
|
Lierse Kempenzonen II | 12 | 4 | 4 | 4 | 15:24 | -9 | 16 |
| 11 |
|
SK Deinze II | 12 | 4 | 1 | 7 | 11:22 | -11 | 13 |
| 12 |
|
RFC Seraing II | 12 | 3 | 0 | 9 | 11:29 | -18 | 9 |
| 13 |
|
KV Kortrijk II | 12 | 1 | 3 | 8 | 12:27 | -15 | 6 |
| 14 |
|
Lommel SK II | 12 | 1 | 3 | 8 | 10:25 | -15 | 6 |
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