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| 22.11.2021 | 19:30 | KAS Eupen II | - | Excelsior Virton II | 2:3 | |
| 19:30 | Royal Excel Mouscron II | - | Lommel SK II | 4:0 | ||
| 19:30 | KV Kortrijk II | - | KVC Westerlo II | 3:3 | ||
| 20:00 | K Beerschot VA II | - | SK Beveren II | 2:1 | ||
| 20:00 | Lierse Kempenzonen II | - | RWDM Brussels FC II | 0:2 | ||
| 20:00 | RFC Seraing II | - | Union St. Gilloise II | 0:5 | ||
| 09.12.2021 | 20:00 | SK Deinze II | - | KV Oostende II | 0:5 |
| » Classement | équipe recevante | à l'extérieur | Premier tour | Second tour |
| # | Équipe | M. | G. | N. | P. | Buts | Diff. | Pts. | |
|---|---|---|---|---|---|---|---|---|---|
| 1 |
|
KAS Eupen II | 11 | 8 | 1 | 2 | 26:13 | 13 | 25 |
| 2 |
|
KV Oostende II | 11 | 6 | 5 | 0 | 29:10 | 19 | 23 |
| 3 |
|
K Beerschot VA II | 11 | 7 | 2 | 2 | 24:11 | 13 | 23 |
| 4 |
|
Excelsior Virton II | 11 | 6 | 2 | 3 | 27:28 | -1 | 20 |
| 5 |
|
RWDM Brussels FC II | 11 | 6 | 1 | 4 | 27:22 | 5 | 19 |
| 6 |
|
Royal Excel Mouscron II | 11 | 5 | 1 | 5 | 17:10 | 7 | 16 |
| 7 |
|
SK Beveren II | 11 | 5 | 1 | 5 | 17:11 | 6 | 16 |
| 8 |
|
KVC Westerlo II | 11 | 5 | 1 | 5 | 15:16 | -1 | 16 |
| 9 |
|
Lierse Kempenzonen II | 11 | 4 | 3 | 4 | 13:22 | -9 | 15 |
| 10 |
|
Union St. Gilloise II | 11 | 4 | 2 | 5 | 12:10 | 2 | 14 |
| 11 |
|
SK Deinze II | 11 | 4 | 1 | 6 | 11:20 | -9 | 13 |
| 12 |
|
RFC Seraing II | 11 | 3 | 0 | 8 | 9:26 | -17 | 9 |
| 13 |
|
Lommel SK II | 11 | 1 | 3 | 7 | 10:22 | -12 | 6 |
| 14 |
|
KV Kortrijk II | 11 | 0 | 3 | 8 | 9:25 | -16 | 3 |
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