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| 20.09.2021 | 19:30 | KAS Eupen II | - | KV Kortrijk II | 4:0 (4:0) | |
| 19:30 | Royal Excel Mouscron II | - | SK Deinze II | 3:0 (1:0) | ||
| 19:30 | KV Oostende II | - | K Beerschot VA II | 1:1 (0:0) | ||
| 20:00 | Union St. Gilloise II | - | Lierse Kempenzonen II | 1:2 (0:0) | ||
| 20:00 | Excelsior Virton II | - | KVC Westerlo II | 1:3 (1:1) | ||
| 20:00 | RFC Seraing II | - | SK Beveren II | 0:2 (0:1) | ||
| 20:30 | RWDM Brussels FC II | - | Lommel SK II | 2:1 (1:0) |
| » Classement | équipe recevante | à l'extérieur | Premier tour | Second tour |
| # | Équipe | M. | G. | N. | P. | Buts | Diff. | Pts. | |
|---|---|---|---|---|---|---|---|---|---|
| 1 |
|
SK Beveren II | 4 | 3 | 0 | 1 | 9:1 | 8 | 9 |
| 2 |
|
Royal Excel Mouscron II | 4 | 3 | 0 | 1 | 6:1 | 5 | 9 |
| 3 |
|
Lierse Kempenzonen II | 4 | 3 | 0 | 1 | 5:8 | -3 | 9 |
| 4 |
|
KV Oostende II | 4 | 2 | 2 | 0 | 14:5 | 9 | 8 |
| 5 |
|
KAS Eupen II | 4 | 2 | 1 | 1 | 10:5 | 5 | 7 |
| 6 |
|
KVC Westerlo II | 4 | 2 | 0 | 2 | 5:4 | 1 | 6 |
| 7 |
|
RFC Seraing II | 4 | 2 | 0 | 2 | 4:4 | 0 | 6 |
| 8 |
|
SK Deinze II | 4 | 2 | 0 | 2 | 2:4 | -2 | 6 |
| 9 |
|
K Beerschot VA II | 4 | 1 | 2 | 1 | 3:4 | -1 | 5 |
| 10 |
|
RWDM Brussels FC II | 4 | 1 | 1 | 2 | 8:9 | -1 | 4 |
| 11 |
|
Union St. Gilloise II | 4 | 1 | 1 | 2 | 4:6 | -2 | 4 |
| 12 |
|
Excelsior Virton II | 4 | 1 | 1 | 2 | 5:14 | -9 | 4 |
| 13 |
|
Lommel SK II | 4 | 1 | 0 | 3 | 6:8 | -2 | 3 |
| 14 |
|
KV Kortrijk II | 4 | 0 | 0 | 4 | 0:8 | -8 | 0 |
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