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| 27.09.2021 | 19:30 | Royal Excel Mouscron II | - | RFC Seraing II | 0:1 | |
| 19:30 | SK Beveren II | - | KAS Eupen II | 1:2 | ||
| 19:30 | KV Kortrijk II | - | Excelsior Virton II | 1:4 | ||
| 20:00 | KVC Westerlo II | - | RWDM Brussels FC II | 1:3 | ||
| 20:00 | Lierse Kempenzonen II | - | SK Deinze II | 2:1 | ||
| 20:00 | Lommel SK II | - | KV Oostende II | 2:2 | ||
| 20:00 | K Beerschot VA II | - | Union St. Gilloise II | 0:1 |
| » Classement | équipe recevante | à l'extérieur | Premier tour | Second tour |
| # | Équipe | M. | G. | N. | P. | Buts | Diff. | Pts. | |
|---|---|---|---|---|---|---|---|---|---|
| 1 |
|
Lierse Kempenzonen II | 5 | 4 | 0 | 1 | 7:9 | -2 | 12 |
| 2 |
|
KAS Eupen II | 5 | 3 | 1 | 1 | 12:6 | 6 | 10 |
| 3 |
|
KV Oostende II | 5 | 2 | 3 | 0 | 16:7 | 9 | 9 |
| 4 |
|
SK Beveren II | 5 | 3 | 0 | 2 | 10:3 | 7 | 9 |
| 5 |
|
Royal Excel Mouscron II | 5 | 3 | 0 | 2 | 6:2 | 4 | 9 |
| 6 |
|
RFC Seraing II | 5 | 3 | 0 | 2 | 5:4 | 1 | 9 |
| 7 |
|
RWDM Brussels FC II | 5 | 2 | 1 | 2 | 11:10 | 1 | 7 |
| 8 |
|
Union St. Gilloise II | 5 | 2 | 1 | 2 | 5:6 | -1 | 7 |
| 9 |
|
Excelsior Virton II | 5 | 2 | 1 | 2 | 9:15 | -6 | 7 |
| 10 |
|
KVC Westerlo II | 5 | 2 | 0 | 3 | 6:7 | -1 | 6 |
| 11 |
|
SK Deinze II | 5 | 2 | 0 | 3 | 3:6 | -3 | 6 |
| 12 |
|
K Beerschot VA II | 5 | 1 | 2 | 2 | 3:5 | -2 | 5 |
| 13 |
|
Lommel SK II | 5 | 1 | 1 | 3 | 8:10 | -2 | 4 |
| 14 |
|
KV Kortrijk II | 5 | 0 | 0 | 5 | 1:12 | -11 | 0 |
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