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| 01.11.2021 | 14:00 | RWDM Brussels FC II | - | SK Beveren II | 2:1 | |
| 14:30 | KAS Eupen II | - | SK Deinze II | 3:1 | ||
| 16:00 | RFC Seraing II | - | Excelsior Virton II | 3:4 | ||
| 19:30 | Royal Excel Mouscron II | - | Union St. Gilloise II | 1:1 | ||
| 19:30 | KV Kortrijk II | - | Lommel SK II | 1:1 | ||
| 20:00 | Lierse Kempenzonen II | - | KV Oostende II | 2:2 | ||
| 20:00 | KVC Westerlo II | - | K Beerschot VA II | 1:3 |
| » Classement | équipe recevante | à l'extérieur | Premier tour | Second tour |
| # | Équipe | M. | G. | N. | P. | Buts | Diff. | Pts. | |
|---|---|---|---|---|---|---|---|---|---|
| 1 |
|
KAS Eupen II | 9 | 7 | 1 | 1 | 23:10 | 13 | 22 |
| 2 |
|
KV Oostende II | 9 | 4 | 5 | 0 | 21:10 | 11 | 17 |
| 3 |
|
K Beerschot VA II | 9 | 5 | 2 | 2 | 19:9 | 10 | 17 |
| 4 |
|
SK Beveren II | 9 | 5 | 1 | 3 | 16:8 | 8 | 16 |
| 5 |
|
Lierse Kempenzonen II | 9 | 4 | 3 | 2 | 12:17 | -5 | 15 |
| 6 |
|
Excelsior Virton II | 9 | 4 | 2 | 3 | 22:25 | -3 | 14 |
| 7 |
|
Royal Excel Mouscron II | 9 | 4 | 1 | 4 | 12:8 | 4 | 13 |
| 8 |
|
RWDM Brussels FC II | 9 | 4 | 1 | 4 | 21:20 | 1 | 13 |
| 9 |
|
KVC Westerlo II | 9 | 4 | 0 | 5 | 11:13 | -2 | 12 |
| 10 |
|
Union St. Gilloise II | 9 | 3 | 2 | 4 | 7:9 | -2 | 11 |
| 11 |
|
SK Deinze II | 9 | 3 | 1 | 5 | 10:15 | -5 | 10 |
| 12 |
|
RFC Seraing II | 9 | 3 | 0 | 6 | 9:18 | -9 | 9 |
| 13 |
|
Lommel SK II | 9 | 1 | 3 | 5 | 10:17 | -7 | 6 |
| 14 |
|
KV Kortrijk II | 9 | 0 | 2 | 7 | 4:18 | -14 | 2 |
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