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| 08.11.2021 | 19:30 | KV Oostende II | - | RFC Seraing II | 3:0 | |
| 20:00 | Union St. Gilloise II | - | KAS Eupen II | 0:1 | ||
| 20:00 | K Beerschot VA II | - | Lierse Kempenzonen II | 3:1 | ||
| 20:00 | Excelsior Virton II | - | Royal Excel Mouscron II | 2:1 | ||
| 20:00 | Lommel SK II | - | SK Deinze II | 0:1 | ||
| 20:00 | KVC Westerlo II | - | SK Beveren II | 1:0 | ||
| 20:30 | RWDM Brussels FC II | - | KV Kortrijk II | 4:2 |
| » Classement | équipe recevante | à l'extérieur | Premier tour | Second tour |
| # | Équipe | M. | G. | N. | P. | Buts | Diff. | Pts. | |
|---|---|---|---|---|---|---|---|---|---|
| 1 |
|
KAS Eupen II | 10 | 8 | 1 | 1 | 24:10 | 14 | 25 |
| 2 |
|
KV Oostende II | 10 | 5 | 5 | 0 | 24:10 | 14 | 20 |
| 3 |
|
K Beerschot VA II | 10 | 6 | 2 | 2 | 22:10 | 12 | 20 |
| 4 |
|
Excelsior Virton II | 10 | 5 | 2 | 3 | 24:26 | -2 | 17 |
| 5 |
|
SK Beveren II | 10 | 5 | 1 | 4 | 16:9 | 7 | 16 |
| 6 |
|
RWDM Brussels FC II | 10 | 5 | 1 | 4 | 25:22 | 3 | 16 |
| 7 |
|
KVC Westerlo II | 10 | 5 | 0 | 5 | 12:13 | -1 | 15 |
| 8 |
|
Lierse Kempenzonen II | 10 | 4 | 3 | 3 | 13:20 | -7 | 15 |
| 9 |
|
Royal Excel Mouscron II | 10 | 4 | 1 | 5 | 13:10 | 3 | 13 |
| 10 |
|
SK Deinze II | 10 | 4 | 1 | 5 | 11:15 | -4 | 13 |
| 11 |
|
Union St. Gilloise II | 10 | 3 | 2 | 5 | 7:10 | -3 | 11 |
| 12 |
|
RFC Seraing II | 10 | 3 | 0 | 7 | 9:21 | -12 | 9 |
| 13 |
|
Lommel SK II | 10 | 1 | 3 | 6 | 10:18 | -8 | 6 |
| 14 |
|
KV Kortrijk II | 10 | 0 | 2 | 8 | 6:22 | -16 | 2 |
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