 |
 |
|
|
| 19.02.2022 | 16:00 | AE Lárissa | - | Olympiakos Piraeus II | 2:1 (1:0) | |
| 20.02.2022 | 13:45 | AO Trikala | - | Panserraikos | 1:1 (1:1) | |
| 13:45 | PAOK Saloniki II | - | AEP Iraklis FC | 0:0 (0:0) | ||
| 13:45 | Niki Volou FC | - | Apollon Pontou | 1:0 (1:0) | ||
| 13:45 | Almopos Arideas | - | Anagennisi Karditsa | 1:0 (1:0) | ||
| 13:45 | AO Kavala | - | Pierikos Katerini | 1:2 (1:1) | ||
| 19:00 | Thesprotos | - | Xanthi FC | 0:0 (0:0) | ||
| 16.03.2022 | 14:00 | Olympiakos Volou | - | Veria FC | 0:2 (0:1) |
| » Classement | équipe recevante | à l'extérieur | Premier tour | Second tour |
| # | Équipe | M. | G. | N. | P. | Buts | Diff. | Pts. | |
|---|---|---|---|---|---|---|---|---|---|
| 1 |
|
Veria FC | 19 | 14 | 3 | 2 | 42:15 | 27 | 45 |
| 2 |
|
AE Lárissa | 18 | 11 | 6 | 1 | 25:6 | 19 | 39 |
| 3 |
|
Anagennisi Karditsa | 19 | 10 | 4 | 5 | 30:18 | 12 | 34 |
| 4 |
|
Xanthi FC | 18 | 9 | 6 | 3 | 28:12 | 16 | 33 |
| 5 |
|
AEP Iraklis FC | 19 | 6 | 11 | 2 | 22:12 | 10 | 29 |
| 6 |
|
PAOK Saloniki II | 19 | 7 | 8 | 4 | 24:17 | 7 | 29 |
| 7 |
|
Olympiakos Piraeus II | 19 | 7 | 7 | 5 | 23:20 | 3 | 28 |
| 8 |
|
Niki Volou FC | 19 | 7 | 6 | 6 | 22:14 | 8 | 27 |
| 9 |
|
Almopos Arideas | 19 | 7 | 4 | 8 | 24:20 | 4 | 25 |
| 10 |
|
Thesprotos | 19 | 6 | 5 | 8 | 24:20 | 4 | 23 |
| 11 |
|
Apollon Pontou | 19 | 4 | 6 | 9 | 21:29 | -8 | 18 |
| 12 |
|
Pierikos Katerini | 19 | 4 | 6 | 9 | 18:27 | -9 | 18 |
| 13 |
|
Panserraikos | 19 | 3 | 8 | 8 | 20:29 | -9 | 17 |
| 14 |
|
AO Trikala | 19 | 4 | 5 | 10 | 14:29 | -15 | 17 |
| 15 |
|
Olympiakos Volou | 19 | 4 | 4 | 11 | 22:34 | -12 | 16 |
| 16 |
|
Apollon Lárissa | 18 | 3 | 7 | 8 | 13:25 | -12 | 16 |
| 17 |
|
AO Kavala | 19 | 4 | 4 | 11 | 15:60 | -45 | 16 |
| Play-off | |
| Relégation |
