 |
 |
|
| 13.11.2021 | 16:00 | Gallos Blancos | - | FC Juárez | 1:1 (1:0) | |
| 16:00 | Deportivo Toluca | - | CF Pachuca | 4:1 (3:0) | ||
| 16:00 | Atlas Guadalajara | - | UANL Tigres | 1:2 (0:0) | ||
| 16:00 | Santos Laguna | - | Deportivo Guadalajara | 0:1 (0:0) | ||
| 16:00 | CF Monterrey | - | Club León | 0:3 (0:2) | ||
| 16:30 | Mazatlán FC | - | Club Necaxa | 2:1 (0:0) | ||
| 17:00 | Pumas UNAM | - | Club Tijuana | 0:0 (0:0) | ||
| 23:00 | CF América | - | Puebla FC | 1:1 (1:0) |
| » Classement | équipe recevante | à l'extérieur | Premier tour | Second tour |
| # | Équipe | M. | G. | N. | P. | Buts | Diff. | Pts. | |
|---|---|---|---|---|---|---|---|---|---|
| 1 |
|
Deportivo Guadalajara | 15 | 11 | 3 | 1 | 47:15 | 32 | 36 |
| 2 |
|
Deportivo Toluca | 16 | 10 | 5 | 1 | 30:15 | 15 | 35 |
| 3 |
|
Pumas UNAM | 15 | 9 | 3 | 3 | 24:13 | 11 | 30 |
| 4 |
|
Santos Laguna | 15 | 8 | 4 | 3 | 29:19 | 10 | 28 |
| 5 |
|
UANL Tigres | 15 | 8 | 3 | 4 | 27:17 | 10 | 27 |
| 6 |
|
CF Pachuca | 15 | 8 | 3 | 4 | 20:16 | 4 | 27 |
| 7 |
|
Club León | 15 | 7 | 3 | 5 | 24:20 | 4 | 24 |
| 8 |
|
Cruz Azul | 15 | 7 | 3 | 5 | 18:17 | 1 | 24 |
| 9 |
|
Club Tijuana | 15 | 7 | 2 | 6 | 20:21 | -1 | 23 |
| 10 |
|
Club Necaxa | 15 | 6 | 2 | 7 | 22:18 | 4 | 20 |
| 11 |
|
Atlas Guadalajara | 15 | 6 | 1 | 8 | 32:31 | 1 | 19 |
| 12 |
|
Puebla FC | 15 | 5 | 4 | 6 | 24:25 | -1 | 19 |
| 13 |
|
CF Monterrey | 15 | 5 | 4 | 6 | 21:27 | -6 | 19 |
| 14 |
|
Mazatlán FC | 16 | 5 | 1 | 10 | 25:47 | -22 | 16 |
| 15 |
|
CF América | 15 | 4 | 2 | 9 | 20:25 | -5 | 14 |
| 16 |
|
Gallos Blancos | 15 | 2 | 5 | 8 | 17:22 | -5 | 11 |
| 17 |
|
FC Juárez | 15 | 1 | 3 | 11 | 11:30 | -19 | 6 |
| 18 |
|
Atlético San Luis | 15 | 1 | 1 | 13 | 11:44 | -33 | 4 |
| Play-off |
